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  • Nano-encapsulation of a novel anti-Ran-GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells 

    Haggag YA, Matchett KB, Dakir E-H et al (2017) Nano-encapsulation of a novel anti-Ran- GTPase peptide for blockade of regulator of chromosome condensation 1 (RCC1) function in MDA-MB-231 breast cancer cells. International Journal of Pharmaceutics. 521(1-2): 40-53.
    Ran is a small ras-related GTPase and is highly expressed in aggressive breast carcinoma. Overexpression induces malignant transformation and drives metastatic growth. We have designed a novel series of anti-Ran-GTPase ...
  • A proposed minimum data set for international primary care optometry: a modified Delphi study 

    Davey CJ, Slade SV and Shickle D. A proposed minimum data set for international primary care optometry: a modified Delphi study. Ophthalmic and Physiological Optics. Article in Press.
    Purpose: To identify a minimum list of metrics of international relevance to public health, research and service development which can be extracted from practice management systems and electronic patient records in primary ...
  • The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design 

    Childers MC, Towse CL and Daggett V (2016) The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design. Protein Engineering, Design and Selection. 29(7): 271-280.
    The conformational propensities of amino acids are an amalgamation of sequence effects, environmental effects and underlying intrinsic behavior. Many have attempted to investigate neighboring residue effects to aid in our ...
  • Tunable Supramolecular Hydrogels for Selection of Lineage-Guiding Metabolites in Stem Cell Cultures 

    Alakpa EV, Jayawarna V, Lampel A et al (2016) Tunable Supramolecular Hydrogels for Selection of Lineage-Guiding Metabolites in Stem Cell Cultures. Chem. 1(2): 298-319.
    Stem cells are known to differentiate in response to the chemical and mechanical properties of the substrates on which they are cultured. Thus, supramolecular biomaterials with tunable properties are well suited for the ...
  • MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin 

    Kalafatovic D, Nobis M, Javid N et al (2015) MMP-9 triggered micelle-to-fibre transitions for slow release of doxorubicin. Biomaterials Sciences. 3(2): 246-249.
    Phenylacetyl-peptide amphiphiles were designed, which upon cleavage by a disease-associated enzyme reconfigure from micellar aggregates to fibres. Upon this morphological change, a doxorubicin payload could be retained in ...
  • Differential Self-Assembly and Tunable Emission of Aromatic Peptide Bola-Amphiphiles Containing Perylene Bisimide in Polar Solvents Including Water 

    Bai S, Debnath S, Javid N et al (2014) Differential Self-Assembly and Tunable Emission of Aromatic Peptide Bola-Amphiphiles Containing Perylene Bisimide in Polar Solvents Including Water. Langmuir. 30(25): 7576-7584.
    We demonstrate the self-assembly of bola-amphiphile-type conjugates of dipeptides and perylene bisimide (PBI) in water and other polar solvents. Depending on the nature of the peptide used (glycine-tyrosine, GY, or ...
  • Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels 

    Berdugo C, Nalluri SKM, Javid N et al (2015) Dynamic Peptide Library for the Discovery of Charge Transfer Hydrogels. ACS Applied Materials and Interfaces. 7(46): 25946-25954.
    Coupling of peptide self-assembly to dynamic sequence exchange provides a useful approach for the discovery of self-assembling materials. In here, we demonstrate the discovery and optimization of aqueous, gel-phase ...
  • Filtration Suppresses Laser-Induced Nucleation of Glycine in Aqueous Solutions 

    Javid N, Kendall T, Burns IS et al (2016) Filtration Suppresses Laser-Induced Nucleation of Glycine in Aqueous Solutions. Crystal Growth and Design. 16(8): 4196-4202.
    We demonstrate that nanofiltration of aqueous glycine solutions has a pronounced effect on laser-induced nucleation. Two nucleation regimes were observed in nonfiltered, irradiated solutions under isothermal conditions: a ...
  • Biocatalytic Amide Condensation and Gelation Controlled by Light 

    Sahoo JK, Nalluri SKM, Javid N et al (2014) Biocatalytic Amide Condensation and Gelation Controlled by Light. Chemical Communication. 50: 5462-5464.
    We report on a supramolecular self-assembly system that displays coupled light switching, biocatalytic condensation/hydrolysis and gelation. The equilibrium state of this system can be regulated by light, favouring in situ ...
  • Biocatalytic Self-Assembly of Supramolecular Charge Transfer Nanostructures Based on n-Type Semiconductor-Appended Peptide 

    Nalluri SKM, Berdugo C, Javid N et al (2014) Biocatalytic Self-Assembly of Supramolecular Charge Transfer Nanostructures Based on n-Type Semiconductor-Appended Peptide. Angewandte Chemie. International Ed. 53(23): 5882-5887.
    The reversible in situ formation of a self-assembly building block (naphthalenediimide (NDI)–dipeptide conjugate) by enzymatic condensation of NDI-functionalized tyrosine (NDI-Y) and phenylalanine-amide (F-NH2) to form ...
  • Discovery of Catalytic Phages by Biocatalytic Self-Assembly 

    Maeda Y, Javid N, Duncan K et al (2014) Discovery of Catalytic Phages by Biocatalytic Self-Assembly. Journal of the American Chemical Society. 136(45): 15893-15896.
    Discovery of new catalysts for demanding aqueous reactions is challenging. Here, we describe methodology for selection of catalytic phages by taking advantage of localized assembly of the product of the catalytic reaction ...
  • Exploring the Sequence Space for (tri-) Peptide Self-assembly to Design and Discover New Hydrogels 

    Frederix PWJM, Scott GG, Abul-Haija YM et al (2015) Exploring the Sequence Space for (tri-) Peptide Self-assembly to Design and Discover New Hydrogels. Nature Chemistry. 7: 30-37.
    Peptides that self-assemble into nanostructures are of tremendous interest for biological, medical, photonic and nanotechnological applications. The enormous sequence space that is available from 20 amino acids probably ...
  • X-ray crystallography and its role in understanding physicochemical properties of pharmaceutical cocrystals 

    Aitipamula S and Vangala VR (2017) X-ray crystallography and its role in understanding physicochemical properties of pharmaceutical cocrystals. Journal of the Indian Institute of Science. Article in Press.
    Properties of a matter are intrinsically dependent upon the internal arrangement of molecules in the solid state. Therefore, knowledge of 3-dimensional structure of the matter is prerequisite for structure-property ...
  • To Cut a Long Story Short: Formal Chronological Modelling for the Late Neolithic Site of Ness of Brodgar, Orkney 

    Card N, Mainland I, Timpany S et al (2017) To cut a long story short: Formal chronological modelling for the late neolithic site of Ness of Brodgar, Orkney. European Journal of Archaeology. Accepted for publication.
    In the context of unanswered questions about the nature and development of the Late Neolithic in Orkney, we present a summary of research up to 2015 on the major site at the Ness of Brodgar, Mainland Orkney, concentrating ...
  • Modulation of Neurotransmission by the GABAB Receptor 

    Kantamneni S (2016) Modulation of Neurotransmission by the GABAB Receptor. In: Colombo G (ed) GABAB Receptor. The Receptors [series] vol 29. Basel: Springer International Publishing AG. pp 109-128.
    Most inhibitory signals are mediated via γ-aminobutyric acid (GABA) receptors whereas glutamate receptors mediate most excitatory signals (Trends Neurosci 14:515–519, 1991; Annu Rev Neurosci 17:31–108, 1994). Many factors ...
  • Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis 

    Pinnock A, Shivshetty N, Roy S et al (2017) Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis. Graeve’s Archive for Clinical and Experimental Ophthalmology. 255(2): 333-342.
    In the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell ...
  • Collagen–Poly(N-isopropylacrylamide) Hydrogels with Tunable Properties 

    Barnes AL, Genever PG, Rimmer S et al (2016) Biomacromolecules (2016) Collagen–Poly(N-isopropylacrylamide) Hydrogels with Tunable Properties. Biomacromolecules. 17(3): 723-734.
    There is a lack of hydrogel materials whose properties can be tuned at the point of use. Biological hydrogels, such as collagen, gelate at physiological temperatures; however, they are not always ideal as scaffolds because ...
  • Thermo-responsive microcarriers based on poly(N-isopropylacrylamide) 

    Zhang J, Cui Z, Field R et al (2015) Thermo-responsive microcarriers based on poly(N-isopropylacrylamide). European Polymer Journal. 67: 346-364.
    Microcarrier cell culture systems provide an attractive alternative to the conventional monolayer cell culture for cell amplification, due to their high surface area-to-volume ratio. Unlike enzymatic methods for removing ...
  • Separating topographical and chemical analysis of nanostructure of polymer composite in low voltage SEM 

    Wan Q, Plenderleith RA, Dapor M et al (2015) Separating topographical and chemical analysis of nanostructure of polymer composite in low voltage SEM. Journal of Physics: Conference Series. 644. Conference 1.
    The possibility of separating the topographical and chemical information in a polymer nano-composite using low-voltage SEM imaging is demonstrated, when images are acquired with a Concentric Backscattered (CBS) detector. ...
  • The reference frame for encoding and retention of motion depends on stimulus set size 

    Huynh D, Tripathy SP, Bedell HE et al (2017) The reference frame for encoding and retention of motion depends on stimulus set size. Attention, Perception and Psychophysics. Article in Press.
    The goal of this study was to investigate the reference frames used in perceptual encoding and storage of visual motion information. In our experiments, observers viewed multiple moving objects and reported the direction ...

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