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  • Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs 

    Pagire SK, Jadav N, Vangala VR et al (2017) Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs. Journal of Pharmaceutical Sciences. Article in Press.
    Polymorphism in active pharmaceutical ingredients (APIs) can be regarded as critical for the potential that crystal form can have on the quality, efficacy and safety of the final drug product. The current contribution aims ...
  • Systematic associations between germ-line mutations and human cancers 

    Al-Shammari M, Tobin DJ and Peng Y (2016) Systematic associations between germ-line mutations and human cancers. International Journal of Computational Biology and Drug Design 9(1-2): 135-148.
    The revolution in Big Data has opened the gate for new research challenges in biomedical science. The aim of this study was to investigate whether germ-line gene mutations are a significant factor in 29 major primary human ...
  • Erythropoietin drives breast cancer progression by activation of its receptor EPOR 

    Chan KK, Matchett KB, Coulter JA et al (2017) Erythropoietin drives breast cancer progression by activation of its receptor EPOR. Oncotarget. Accepted for publication.
    Breast cancer is a leading cause of cancer-related deaths. Anemia is common in breast cancer patients and can be treated with blood transfusions or with recombinant erythropoietin (EPO) to stimulate red blood cell ...
  • Differential processing of the direction and focus of expansion of optic flow stimuli in areas MST and V3A of the human visual cortex 

    Strong SL, Silson EH, Gouws AD et al (2017) Differential processing of the direction and focus of expansion of optic flow stimuli in areas MST and V3A of the human visual cortex. Journal of Neurophysiology. Article in Press.
    Human neuropsychological and neuroimaging studies have raised the possibility that different attributes of optic flow stimuli, namely radial direction and the position of the focus of expansion (FOE), are processed within ...
  • Multi-electron reduction of sulfur and carbon disulfide using binuclear uranium(III) borohydride complexes 

    Arnold PL, Stevens CJ, Bell NL, Lord RM, Goldberg JM, Nichol GS and Love JB (2017) Multi-electron reduction of sulfur and carbon disulfide using binuclear uranium(III) borohydride complexes. Chemical Science. Online before print. DOI: 10.1039/c7sc00382j
    The first use of a dinuclear UIII/UIII complex in the activation of small molecules is reported. The octadentate Schiff-base pyrrole, anthracene-hinged ‘Pacman’ ligand LA combines two strongly reducing UIII centres and ...
  • Targeting HOX/PBX dimers in cancer 

    Morgan R, El-Tanani M, Hunter KD et al (2017) Targeting HOX/PBX dimers in cancer. Oncotarget. Article in Press.
    The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also ...
  • Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation 

    McLean SL, Harte MK, Neill JC and Young AMJ (2017) Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation. Journal of Psychopharmacology. Accepted for publication Mar 2017.
    Rationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and ...
  • The mechanism of hydrogen-bonded complex formation between ibuprofen and nanocrystalline hydroxyapatite 

    Ryabenkova Y, Jadav N, Conte M et al (2017) The mechanism of hydrogen-bonded complex formation between ibuprofen and nanocrystalline hydroxyapatite. Langmuir. Accepted for publication.
    Nanocrystalline hydroxyapatite (nanoHA) is the main hard component of bone and has potential to be used to promote osseointegration of implants and to treat bone defects. Here, using active pharmaceutical ingredients (APIs) ...
  • Genetics of type 5 M protein of Streptococcus pyogenes 

    Kehoe MA, Miller L, Poirier TP et al (1987) Genetics of type 5 M protein of Streptococcus pyogenes. In: Ferretti JJ and Curtiss R III (Eds.) Streptococcal Genetics. Washington, US: ASM Publications: 112-116.
  • The mutagenic activity of ethylmethanesulphonate, benzidine and benzo[a]pyrene at the hprt locus of wild-type L5178Y mouse lymphoma cells 

    Kennelly JC, Clare CB, Campbell J et al (1990) The mutagenic activity of ethylmethanesulphonate, benzidine and benzo[a]pyrene at the hprt locus of wild-type L5178Y mouse lymphoma cells. Mutagenesis. 5(Supplement): 21-26.
    Ethylmethanesulphonate (EMS), benzidine (BZD) and benzo[a]pyrene (B[a]P) were assayed for ability to induce mutation at the hprt locus of wild-type L5178Y mouse lymphoma cells. EMS was assayed in the absence of metabolic ...
  • Multiple changes in cell wall antigens of isogenic mutants of Streptococcus mutans 

    Harrington DJ and Russell RRB (1993) Multiple changes in cell wall antigens of isogenic mutants of Streptococcus mutans. Journal of Bacteriology. 175(18): 5925-5933.
    Isogenic mutants of Streptococcus mutans LT11, deficient in the production of the wall-associated protein antigens A and B, were generated by recombinant DNA technology. The hydrophobicity, adherence, and aggregation of ...
  • Identification and characterisation of two extracellular proteases of Streptococcus mutans 

    Harrington DJ and Russell RRB (1994) Identification and characterisation of two extracellular proteases of Streptococcus mutans. FEMS Microbiology Letters. 121(2): 237-241.
    Streptococcus mutans was shown to produce two extracellular proteases capable of degrading both gelatin and collagen-like substrates. These enzymes have molecular masses of 52 and 50 kDa when analysed by SDS-PAGE. Both ...
  • Identity of Streptococcus mutans Surface Protein Antigen III and Wall-Associated Protein Antigen A of Streptococcus mutans 

    Russell WR, Harrington DJ and Russell RRB (1995) Identity of Streptococcus mutans Surface Protein Antigen III and Wall-Associated Protein Antigen A of Streptococcus mutans. Infection and Immunity. 63(2): 733-735.
    Preparations of Streptococcus mutans surface proteins AgIII and antigen A from different laboratories were compared with regard to amino acid composition, N-terminal amino acid sequence, electrophoretic mobility, and ...
  • Identification and Genetic Characterisation of Melibiose-Negative Isolates of Streptococcus mutans 

    Colby SM, Harrington DJ and Russell RRB (1995) Identification and Genetic Characterisation of Melibiose-Negative Isolates of Streptococcus mutans. Caries Research. 29(5): 407-412.
    Streptococcus mutans is frequently identified on the basis of phenotypic characteristics such as the ability to ferment carbohydrates. The usefulness of some of these identification tests may be limited in the case of ...
  • Bacterial collagenases and collagen-degrading enzymes and their potential role in human disease 

    Harrington DJ (1996) Bacterial collagenases and collagen-degrading enzymes and their potential role in human disease. Infection and Immunity. 64(6): 1885-1891.
  • Identification of methionine-processed HPr in the equine pathogen Streptococcus equi 

    Sutcliffe IC, Trigg J and Harrington DJ (2000) Identification of methionine-processed HPr in the equine pathogen Streptococcus equi. Systematic and Applied Microbiology. 23(3): 330-332.
    Using preparative electrophoresis, a low molecular weight protein has been partially purified from a cell extract of the equine pathogen Streptococcus equi susp. equi. N-terminal sequence analysis and Western blotting ...
  • Characterization of acid phosphatase activities in the equine pathogen Streptococcus equi 

    Hamilton A, Harrington DJ and Sutcliffe IC (2000) Characterization of acid phosphatase activities in the equine pathogen Streptococcus equi. Systematic and Applied Microbiology. 23(3): 325-329.
    Acid phosphatases hydrolyse phosphomonoesters at acidic pH in a variety of physiological contexts. The recently defined class C family of acid phosphatases includes the 32 kDa LppC lipoprotein of Streptococcus equisimilis. ...
  • Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus 

    Harrington DJ, Greated SJ, Chanter N et al (2000) Identification of lipoprotein homologues of pneumococcal PsaA in the equine pathogens Streptococcus equi and Streptococcus zooepidemicus. Infection and Immunity. 68(10): 6048-6051.
    Streptococcus equi and Streptococcus zooepidemicus are major etiological agents of upper and lower airway disease in horses. Despite the considerable animal suffering and economic burden associated with these diseases, the ...
  • Surface Immunolocalisation of HPr in the Equine Pathogen Streptococcus equi 

    Dixon S, Haswell M, Harrington DJ et al (2001) Surface immunolocalisation of HPr in the equine pathogen Streptococcus equi. Systematic and Applied Microbiology. 24(4): 486-489.
    We have investigated the surface localisation of the phosphotransferase system protein HPr in the equine pathogen Streptococcus equi subsp. equi using immunogold localisation and transmission electron microscopy. Like the ...
  • The molecular basis of Streptococcus equi infection and disease 

    Harrington DJ, Sutcliffe IC and Chanter N (2002) The molecular basis of Streptococcus equi infection and disease. Microbes and Infection. 4(4): 501-510.
    Streptococcus equi is the aetiological agent of strangles, one of the most prevalent diseases of the horse. The animal suffering and economic burden associated with this disease necessitate effective treatment. Current ...

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