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  • Does an intercalated clinical placement make a difference to learning gain? 

    Wheelhouse RT ( 2017 ) Does an intercalated clinical placement make a difference to learning gain? [Abstract]. Pharmacy Education Conference 2017, Manchester, United Kingdom. Pharmacy Education. 17(1): 188.
    Background Anecdotally, it has long been felt by academic staff that students on the Bradford 5-year sandwich degree programme (intercalated pre-registration training) performed differently on return to university from ...
  • Probing Imidazotetrazine Prodrug Activation Mechanisms 

    Moody CL, Ahmad L, Ashour A and Wheelhouse RT (2017) Probing Imidazotetrazine Prodrug Activation Mechanisms. In: 25th Conference of GP2A, Meeting report. Pharmaceutics 10(4): 97. Poster presentation, 5.15, (P22).
    The archetypal prodrug of the imidazotetrazine class is the anticancer agent temozolomide (TMZ). The prodrug activation kinetics of TMZ show an unusual pH dependence: it is stable in acid and rapidly hydrolyses in alkali ...
  • Mechanisms of Action of Silane-Substituted Anti-Cancer Imidazotetrazines 

    Summers HS, Bradshaw TD, Stevens MFG and Wheelhouse RT (2017) Mechanisms of Action of Silane-Substituted Anti-Cancer Imidazotetrazines. In: 25th Conference of GP2A, Meeting report. Pharmaceutics 10(4): 97. Poster presentation, 5.16, (P23).
    Silane-substituted imidazotetrazines 1,2 were investigated for their activity as anticancer prodrugs related to temozolomide (TMZ). The TMS-derivative 1 showed an activity profile against TMZ susceptible and resistant ...
  • Vision in high-level football officials 

    Baptista AMG, Serra PM, McAlinden C et al (2017) Vision in high-level football officials. PloS ONE. 12(11): e0188463.
    Officiating in football depends, at least to some extent, upon adequate visual function. However, there is no vision standard for football officiating and the nature of the relationship between officiating performance and ...
  • Photobiomodulation of human dermal fibroblasts in vitro: decisive role of cell culture conditions and treatment protocols on experimental outcome 

    Mignon C, Uzunbajakava NE, Raafs B et al (2017) Photobiomodulation of human dermal fibroblasts in vitro: decisive role of cell culture conditions and treatment protocols on experimental outcome. Scientific Reports. 7. No 2797.
    Photobiomodulation-based (LLLT) therapies show tantalizing promise for treatment of skin diseases. Confidence in this approach is blighted however by lamentable inconsistency in published experimental designs, and so ...
  • Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation 

    Weiland D, Brachvogel B, Hornig-Do H-T et al (2018) Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation. Journal of Investigative Dermatology. 138(1): 132-140.
    Accumulation of large-scale mitochondrial DNA (mtDNA) deletions and chronic, subclinical inflammation are concomitant during skin aging, thus raising the question of a causal link. To approach this, we generated mice ...
  • Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes 

    Fajuyigbe D, Lwin SM, Diffey BL et al (2018) Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes. FASEB Journal. Accepted for publication.
    Epidermal DNA damage, especially to the basal layer, is an established cause of keratinocyte cancers (KCs). Large differences in KC incidence (20- to 60-fold) between white and black populations are largely attributable ...
  • The Photoelectrochemistry of Assemblies of Semiconductor Nanoparticles at Interfaces 

    Hickey SG (2018) The Photoelectrochemistry of Assemblies of Semiconductor Nanoparticles at Interfaces. Zeitschrift für Physikalische Chemie. Accepted for publication.
    The application of photoelectrochemical methods presents the researcher with a powerful set of versatile tools by which photoactive materials, such as semiconductor quantum dots, at conductive interfaces may be interrogated. ...
  • Excitable Oil Droplets ‐ FRET Across a Liquid‐Liquid Phase Boundary 

    Gruner LJ, Bahrig L, Ostermann K et al (2016) Excitable Oil Droplets ‐ FRET Across a Liquid‐Liquid Phase Boundary. Chemistry Select. 1(13): 4062-4067.
    FRET forms the basis for energy transfer in biological systems and organisms and it has become an investigative tool in the analysis of protein‐protein interactions and in the study of semiconductors (SC). Until now, FRET ...
  • Considering the ‘Terra Incognita’ and the implications for the Cultural Resource Management of the Arabian Gulf Palaeolandscape 

    Cuttler R, Fitch S and Al-Naimi FA (2011) Considering the ‘Terra Incognita’ and the implications for the Cultural Resource Management of the Arabian Gulf Palaeolandscape. In: Potts D, Al Naboodah H. and Hellyer P (eds.) Archaeology of the United Arab Emirates: Proceedings of the Second Conference on the Archaeology of the UAE. London: Trident press.
    Over recent years a multitude of extensive marine geophysical data sets have been gathered in the Arabian Gulf, chiefly for the purposes of oil and gas exploration. Although such geophysical surveys are primarily ...
  • Hypoxia modulates CCR7 expression in head and neck cancers 

    Basheer HA, Pakanavicius E, Cooper PA et al (2018) Hypoxia modulates CCR7 expression in head and neck cancers. Oral Oncology. 80: 64-73.
    The chemokine receptor CCR7 is expressed on lymphocytes and dendritic cells and is responsible for trafficking of these cells in and out of secondary lymphoid organs. It has recently been shown that CCR7 expression is ...
  • Recovery of low volumes of wear debris from rat stifle joint tissues using a novel particle isolation method 

    Patel J, Sal S, Nuss K et al (2018) Recovery of low volumes of wear debris from rat stifle joint tissues using a novel particle isolation method. Acta Biomaterialia. 71: 339-350.
    Less than optimal particle isolation techniques have impeded analysis of orthopaedic wear debris in vivo. The purpose of this research was to develop and test an improved method for particle isolation from tissue. A volume ...
  • Time and a Place: A luni-solar 'time-reckoner' from 8th millennium BC Scotland 

    Gaffney V, Fitch S, Ramsey E, et al (2013) Time and a Place: A luni-solar 'time-reckoner' from 8th millennium BC Scotland. Internet Archaeology 34. https://doi.org/10.11141/ia.34.1
    Visualisation of the midwinter solstice viewed from the Warren Field pit group The capacity to conceptualise and measure time is amongst the most important achievements of human societies, and the issue of when time was ...
  • Time and Tide: Modelling the effects of landscape change on Population support in the Southern North Sea 

    Fitch S (2013) Time and Tide: Modelling the effects of landscape change on Population support in the Southern North Sea. In: Ch’ng E, Gaffney VL and Chapman H (Eds) Visual Heritage in the Digital Age. Springer Cultural Computing Series. Springer: London. 275-296.
    The submerged landscape of the North Sea has long been known by archaeologists as an area of Mesolithic occupation, yet despite this the nature of the occupation of this landscape has remained poorly understood due to the ...
  • The application of extensive 3D Seismic Reflection Data for the exploration of extensive inundated Palaeolandscapes 

    Fitch S and Gaffney VL (2013) Appendix 3 (Technical Appendix): The application of extensive 3D Seismic Reflection Data for the exploration of extensive inundated Palaeolandscapes. In: Sturt F, Ransley J, Dix J et al (Eds) People and the Sea: A maritime Archaeological Research Agenda for England. Council for British Archaeology Press.
  • Multi-proxy palaeoecological approaches to submerged landscapes: a case study from ‘Doggerland’, in the southern North Sea 

    Gearey BR, Hopla E-J, Boomer I et al (2017) Multi-proxy palaeoecological approaches to submerged landscapes: a case study from ‘Doggerland’, in the southern North Sea. In: Williams M, Hill T, Boomer I et al (Eds) The Archaeological and Forensic Applications of Microfossils: A Deeper Understanding of Human History. The Micropalaeontological Society, Special Publications, Geological Society: London. 35-53.
    Abstract: This paper focuses on the submerged landscapes of the southern North Sea, an area often referred to as Doggerland, which was inundated as a result of relative sea-level rise at the start of the Holocene. The ...
  • The effect of hyperbranched poly(acrylic acid)s on the morphology and size of precipitated nanoscale (fluor)hydroxyapatite 

    Shallcross L, Roche K, Wilcock CJ et al (2017) The effect of hyperbranched poly(acrylic acid)s on the morphology and size of precipitated nanoscale (fluor)hydroxyapatite. Journal of Materials Chemistry B. 5(30): 6027-6033.
    Hydroxyapatite and fluorhydroxyapatite (F)HA nanoparticles were synthesised in the presence of branched poly(acrylic acid)s (PAA) synthesised via reversible addition–fragmentation chain transfer polymerisation and compared ...
  • A self-healable fluorescence active hydrogel based on ionic block copolymers prepared via ring opening polymerization and xanthate mediated RAFT polymerization 

    Banerjee SL, Hoskins R, Swift T, Rimmer S and Singha NK (2018) A self-healable fluorescence active hydrogel based on ionic block copolymers prepared via ring opening polymerization and xanthate mediated RAFT polymerization. Polymer Chemistry. 9(10): 1190-1205.
    In this work we report a facile method to prepare a fluorescence active self-healable hydrogel via incorporation of fluorescence responsive ionic block copolymers (BCPs). Ionic block copolymers were prepared via a combined ...
  • Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms 

    Mancini SJ, Boyd D, Katwan OJ et al (2018) Canagliflozin inhibits interleukin-1ßstimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and –independent mechanisms. Scientific Reports. 8: 5276.
    Recent clinical trials of the hypoglycaemic sodium-glucose co-transporter-2 (SGLT2) inhibitors, which inhibit renal glucose reabsorption, have reported beneficial cardiovascular outcomes. Whether SGLT2 inhibitors directly ...
  • Human S-cone electroretinograms obtained by silent substitution stimulation 

    Maguire J, Parry NRA, Kremers J et al (2018) Human S-cone electroretinograms obtained by silent substitution stimulation. JOSA A. 35(4): B11-B18.
    We used triple silent substitution stimuli to characterize human S-cone electroretinograms (ERGs) in normal trichromats. Short-wavelength-cone (S-cone) ERGs were found to have different morphological features and temporal ...

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