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  • A Bayesian approach to linking archaeological, paleoenvironmental and documentary datasets relating to the settlement of Iceland (Landnám) 

    Schmid MME, Zori D, Erlendsson E et al (2017) A Bayesian approach to linking archaeological, paleoenvironmental and documentary datasets relating to the settlement of Iceland (Landnám). The Holocene. Accepted for publication.
    Icelandic settlement (Landnám) period farmsteads offer opportunities to explore the nature and timing of anthropogenic activities and environmental impacts of the first Holocene farming communities. We employ Bayesian ...
  • Red Lustrous Wheelmade ware: analysis of organic residues in Late Bronze Age trade and storage vessels from the eastern Mediterranean 

    Steele VJ and Stern B (2017) Red Lustrous Wheelmade ware: analysis of organic residues in Late Bronze Age trade and storage vessels from the eastern Mediterranean. Journal of Archaeological Science: Reports. Article in Press.
    Transport and storage vessels in Red Lustrous Wheelmade ware (RLWm ware) were traded across a large area of the eastern Mediterranean for approximately 300 years (c. 1500–1200 BCE) during the Late Bronze Age (c.1600–1000 ...
  • E-Cadherin mediates UVR- and calcium-induced melanin transfer in human skin cells 

    Singh SK, Baker R, Sikkink SK, Nizard C, Schnebert S, Kurfurst R and Tobin DJ (2017) E-Cadherin mediates UVR- and calcium-induced melanin transfer in human skin cells. Experimental Dermatology. Accepted for publication June 2017.
    Skin pigmentation is directed by epidermal-melanin units, characterized by long-lived and dendritic epidermal melanocytes (MC) that interact with viable keratinocytes (KC) to contribute melanin to the epidermis. Previously ...
  • Effects of Isoproterenol on IhERG during K+ changes in HEK293 cells 

    Zhang J, Shang L, Ni Y, Wang T and Ma A (2017) Effects of Isoproterenol on IhERG during K+ changes in HEK293 cells. Presented at: The 28th Great Wall International Congress of Cardiology (GW-ICC), International Congress of Cardiovascular Prevention and Rehabilitation 2017, Asia Pacific Heart Congress 2017, 12–15 October, 2017, Beijing, China.
    Introduction:The human ether-a-go-go related gene (hERG) encodes the pore forming protein which mediates the rapid delayed rectifier K+ current in the heart (IKr). Together with other ion channels hERG determines the cardiac ...
  • Contributions of Individual Face Features to Face Discrimination 

    Logan AJ, Gordon GE and Loffler G (2017) Contributions of Individual Face Features to Face Discrimination. Vision Research. Accepted for publication May 2017.
    Faces are highly complex stimuli that contain a host of information. Such complexity poses the following questions: (a) do observers exhibit preferences for specific information? (b) how does sensitivity to individual ...
  • A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival 

    Mohanty S, Chen Z, Li K et al (2017) A novel theranostic strategy for MMP-14 expressing glioblastomas impacts survival. Molecular Cancer Therapeutics. Article in Press.
    Glioblastoma (GBM) has a dismal prognosis. Evidence from preclinical tumor models and human trials indicates the role of GBM initiating cells (GIC) in GBM drug resistance. Here, we propose a new treatment option with tumor ...
  • Study of hydrogen bonding interactions and chemical reactivity analysis of nitrofurantoin–3-aminobenzoic acid cocrystal using quantum chemical and spectroscopic (IR, Raman, 13C SS-NMR) approaches 

    Shukla A, Khan E, Srivastava K et al (2017) Study of hydrogen bonding interactions and chemical reactivity analysis of nitrofurantoin-3-aminobenzoic acid cocrystal using quantum chemical and spectroscopic (IR, Raman, 13C SS-NMR) approaches. CrsytEngComm. Article in Press.
    Investigations of structural reactivity, molecular interactions and vibrational characterization of pharmaceutical drugs are helpful in understanding their behaviour. The aim of this study is to determine the molecular, ...
  • Effect of gold nanoparticles on H9C2 myoblasts and rat peripheral blood mononuclear cells 

    Zhang J, Ma A and Shang L (2017) Effect of gold nanoparticles on H9C2 myoblasts and rat peripheral blood mononuclear cells. Presented at: 38th World Congress of the International Union of Physiological Sciences (IUPS), Rhythms of Life, Rio de Janeiro, Brazil,1-5 Aug, 2017. Abstract ID: 1095.
    Recent studies have gained positive results using nanoparticles (NPs) in treating atherosclerosis on animals. But their toxicity and application in treating other heart diseases such as heart failure and endocarditis still ...
  • Methoxylated but not hydroxylated flavones elicit significant activity against Parp-1-mediated cell death (Parthanatos) 

    Zhang J, Marsh JR, Tait A, Iqbal MM, Pritchard CJ, Ma A, Shang L and Fatokun A (2017) Methoxylated but not hydroxylated flavones elicit significant activity against Parp-1-mediated cell death (Parthanatos). Presented at: 38th World Congress of the International Union of Physiological Sciences (IUPS), Rhythms of Life, Rio de Janeiro, Brazil,1-5 Aug, 2017. Abstract ID: 631.
    Flavonoids, of which flavones are a sub-group, are plant secondary metabolites found in a variety of natural food sources (e.g., vegetables) and wines. They elicit beneficial roles in health and disease through their ...
  • Anticancer roles of platelets and aspirin tested on A549 cells 

    Shang L, Zhang Z and Chen F (2017) Anticancer roles of platelets and aspirin tested on A549 cells. Presented at: 38th World Congress of the International Union of Physiological Sciences (IUPS), Rhythms of Life, Rio de Janeiro, Brazil,1-5 Aug, 2017. Abstract ID: 375.
    Aspirin, formally known as acetylsalicylic (ASA), is most widely used and cheapest over-the counter drugs. It is used not only for the common fevers, headaches and inflammation, but also for reducing the risk of heart ...
  • Electron deficient organometallics as anti-inflamatory drug candidates 

    Shang L, Zhang J, Pitto-Barry A and Barry NPE (2017) Electron deficient organometallics as anti-inflamatory drug candidates. Presented at: 38th World Congress of the International Union of Physiological Sciences (IUPS), Rhythms of Life, Rio de Janeiro, Brazil,1-5 Aug, 2017. Abstract ID: 374.
    Half-sandwich complexes of precious metals are a versatile class of organometallic compounds. Their accessibility, robustness, and air-stability are examples of the unique properties that allow their applications in various ...
  • Stability of Pharmaceutical Cocrystal During Milling: A Case Study of 1:1 Caffeine-Glutaric Acid 

    Chow PS, Lau G, Ng WK and Vangala VR (2017) Stability of Pharmaceutical Cocrystal During Milling: A Case Study of 1:1 Caffeine-Glutaric Acid. Crystal Growth & Design. Online before print. DOI: https://doi.org/10.1021/acs.cgd.6b01160.
    Despite the rising interest in pharmaceutical cocrystals in the past decade, there is a lack of research in the solid processing of cocrystals downstream to crystallization. Mechanical stress induced by unit operations ...
  • Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine 

    Dul M, Paluch KJ, Healy AM et al (2017) Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine. Journal of Nanoparticle Research. 19:221.
    The aim of this work was to investigate the possibility of covalent cross-linker-free, polyelectrolyte complex formation at the nanoscale between alginic acid (as sodium alginate, ALG) and protamine (PROT). Optimisation ...
  • Sensitivity of Chaos Measures in Detecting Stress in the Focusing Control Mechanism of the Short-Sighted Eye 

    Hampson KM, Cufflin MP and Mallen EAH (2017) Bulletin of Mathematical Biology. Online before print. DOI:10.1007/s11538-017-0310-5
    When fixating on a stationary object, the power of the eye’s lens fluctuates. Studies have suggested that changes in these so-called microfluctuations in accommodation may be a factor in the onset and progression of ...
  • p63 transcription factor regulates nuclear shape and expression of nuclear envelope-associated genes in epidermal keratinocyte 

    Rapisarda V, Malashchuk I, Asamaowei IE, Poterlowicz K, Fessing MY, Sharov AA, Karakesisoglou I, Botchkarev VA and Mardaryev A (2017) p63 transcription factor regulates nuclear shape and expression of nuclear envelope-associated genes in epidermal keratinocytes. The Journal of Investigative Dermatology. Online before print. DOI: 10.1016/j.jid.2017.05.013.
    The maintenance of a proper nuclear architecture and 3D organization of the genes, enhancer elements and transcription machinery plays an essential role in tissue development and regeneration. Here we show that in the ...
  • "Bringing heaven down to earth”: The purpose and place of religion in UK food aid 

    Stewart-Knox B (2017) "Bringing heaven down to earth”: The purpose and place of religion in UK food aid. Social Enterprise Journal. Accepted for publication June 2017.
    This paper uses data from a city with a multi-ethnic, multi-faith population to better understand faith-based food aid. It aims to understand what constitutes faith-based responses to food insecurity; compare the prevalence ...
  • T-type Ca2+ channel regulation by CO: a mechanism for control of cell proliferation 

    Duckles H, Al-Owais MM, Elies J et al (2015)T-type Ca2+ channel regulation by CO: a mechanism for control of cell proliferation. In: Peers C, Kumar P, Wyatt C et al (Eds.) Arterial chemoreceptors in physiology and pathophysiology. London: Springer.
    T-type Ca2+ channels regulate proliferation in a number of tissue types, including vascular smooth muscle and various cancers. In such tissues, up-regulation of the inducible enzyme heme oxygenase-1 (HO-1) is often observed, ...
  • Inhibition of T-type Ca2+ channels by hydrogen sulfide 

    Elies J, Scragg JL, Dallas ML et al (2015) Inhibition of T-type Ca2+ channels by hydrogen sulfide. In: Peers C, Kumar P, Wyatt C et al (Eds.) Arterial chemoreceptors in physiology and pathophysiology. London: Springer.
    T-type Ca2+ channels are a distinct family of low voltage-activated Ca2+ channels which serve many roles in different tissues. Several studies have implicated them, for example, in the adaptive responses to chronic hypoxia ...
  • PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production 

    Garcia-Morales V, Cuíñas A, Elies J et al (2014) PKA and Epac activation mediates cAMP-induced vasorelaxation by increasing endothelial NO production. Vascular Pharmacology. 60(3): 95-101.
    Vascular relaxation induced by 3′,5′-cyclic adenosine monophosphate (cAMP) is both endothelium-dependent and endothelium-independent, although the underlying signaling pathways are not fully understood. Aiming to uncover ...
  • Inhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide 

    Elies J, Dallas ML, Boyle JP et al (2014) Inhibition of the cardiac Na+ channel Nav1.5 by carbon monoxide. Journal of Biological Chemistry. 289(23): 16421-16429.
    Sublethal carbon monoxide (CO) exposure is frequently associated with myocardial arrhythmias, and our recent studies have demonstrated that these may be attributable to modulation of cardiac Na+ channels, causing an increase ...

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