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  • A possible alternative to morphine – inspired by spit 

    Rattray M (2017) A possible alternative to morphine – inspired by spit. The Conversation.
    No abstract
  • SHH signalling mediates astrocyte crosstalk with neurons to confer neuroprotection. 

    Ugbode CI, Smith I, Whalley BJ et al (2017) SHH signalling mediates astrocyte crosstalk with neurons to confer neuroprotection. Journal of Neurochemistry. Accepted for publication.
    Sonic Hedgehog (SHH) is a glycoprotein associated with development that is also expressed in the adult CNS and released after brain injury. Since the SHH receptors PTCH1 (patched homolog-1) and SMO (Smoothened) are highly ...
  • Rationalized Computer-Aided Design of Matrix-Metalloprotease-Selective Prodrugs 

    Jain M, Harburn JJ, Gill JH et al (2017) Rationalized Computer-Aided Design of Matrix- Metalloprotease-Selective Prodrugs. Journal of Medicinal Chemistry. 60(10): 4496-4502.
    Matrix metalloproteinases (MMPs) are central to cancer development and metastasis. They are highly active in the tumor environment and absent or inactive in normal tissues; therefore they represent viable targets for cancer ...
  • Exploring and Exploiting Acceptor Preferences of the Human Polysialyltransferases as a Basis for an Inhibitor Screen 

    Ehrit J, Keys TG, Sutherland M et al (2017) Exploring and Exploiting Acceptor Preferences of the Human Polysialyltransferases as a Basis for an Inhibitor Screen. Accepted for publication.
    α2,8-Linked polysialic acid (polySia) is an oncofoetal antigen with high abundance during embryonic development. It reappears in malignant tumours of neuroendocrine origin. Two polysialyltransferases (polySTs) ST8SiaII and ...
  • Nipple aspirate fluid - a liquid biopsy for diagnosing breast health 

    Shaheed S, Tait C, Kyriacou K et al (2017) Nipple aspirate fluid - a liquid biopsy for diagnosing breast health. Proteomics Clinical Applications. Accepted for Publication.
    Purpose: Nipple secretions are protein-rich and a potential source of breast cancer biomarkers for breast cancer screening. Previous studies of specific proteins have shown limited correlation with clinicopatholigical ...
  • Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands 

    Allison SJ, Sadiq M, Baronou E et al (2017) Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbine ligands. Cancer Letters. Article in Press.
    Organometallic complexes offer the prospect of targeting multiple pathways that are important in cancer biology. Here, the preclinical activity and mechanism(s) of action of a silver-bis(N-heterocyclic carbine) complex ...
  • Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae) 

    Taiwo BJ, Fatokun AA, Olubiyi OO et al (2017) Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae). Bioorganic & Medicinal Chemistry. 25(8): 2327-2335.
    Cancer is now the second-leading cause of mortality and morbidity, behind only heart disease, necessitating urgent development of (chemo)therapeutic interventions to stem the growing burden of cancer cases and cancer ...
  • Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines 

    Ahmed M, Basheer HA, Ayuso JM, Ahmet D, Mazzini M, Patel R, Shnyder SD, Vinader V and Afarinkia K (2017) Agarose Spot as a Comparative Method for in situ Analysis of Simultaneous Chemotactic Responses to Multiple Chemokines. Scientific Reports. 7: 1075.
    We describe a novel protocol to quantitatively and simultaneously compare the chemotactic responses of cells towards different chemokines. In this protocol, droplets of agarose gel containing different chemokines are applied ...
  • Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs 

    Pagire SK, Jadav N, Vangala VR et al (2017) Thermodynamic investigation of carbamazepine-saccharin co-crystal polymorphs. Journal of Pharmaceutical Sciences. Article in Press.
    Polymorphism in active pharmaceutical ingredients (APIs) can be regarded as critical for the potential that crystal form can have on the quality, efficacy and safety of the final drug product. The current contribution aims ...
  • Systematic associations between germ-line mutations and human cancers 

    Al-Shammari M, Tobin DJ and Peng Y (2016) Systematic associations between germ-line mutations and human cancers. International Journal of Computational Biology and Drug Design. 9(1-2): 135-148.
    The revolution in Big Data has opened the gate for new research challenges in biomedical science. The aim of this study was to investigate whether germ-line gene mutations are a significant factor in 29 major primary human ...
  • Erythropoietin drives breast cancer progression by activation of its receptor EPOR 

    Chan KK, Matchett KB, Coulter JA et al (2017) Erythropoietin drives breast cancer progression by activation of its receptor EPOR. Oncotarget. Article in Press.
    Breast cancer is a leading cause of cancer-related deaths. Anemia is common in breast cancer patients and can be treated with blood transfusions or with recombinant erythropoietin (EPO) to stimulate red blood cell ...
  • Differential processing of the direction and focus of expansion of optic flow stimuli in areas MST and V3A of the human visual cortex 

    Strong SL, Silson EH, Gouws AD et al (2017) Differential processing of the direction and focus of expansion of optic flow stimuli in areas MST and V3A of the human visual cortex. Journal of Neurophysiology. Article in Press.
    Human neuropsychological and neuroimaging studies have raised the possibility that different attributes of optic flow stimuli, namely radial direction and the position of the focus of expansion (FOE), are processed within ...
  • Multi-electron reduction of sulfur and carbon disulfide using binuclear uranium(III) borohydride complexes 

    Arnold PL, Stevens CJ, Bell NL, Lord RM, Goldberg JM, Nichol GS and Love JB (2017) Multi-electron reduction of sulfur and carbon disulfide using binuclear uranium(III) borohydride complexes. Chemical Science. Online before print. DOI: 10.1039/c7sc00382j
    The first use of a dinuclear UIII/UIII complex in the activation of small molecules is reported. The octadentate Schiff-base pyrrole, anthracene-hinged ‘Pacman’ ligand LA combines two strongly reducing UIII centres and ...
  • Targeting HOX/PBX dimers in cancer 

    Morgan R, El-Tanani M, Hunter KD et al (2017) Targeting HOX/PBX dimers in cancer. Oncotarget. Article in Press.
    The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they are also ...
  • Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation 

    McLean SL, Harte MK, Neill JC and Young AMJ (2017) Dopamine dysregulation in the prefrontal cortex relates to cognitive deficits in the sub-chronic PCP-model for schizophrenia: a preliminary investigation. Journal of Psychopharmacology. Accepted for publication Mar 2017.
    Rationale: Dopamine dysregulation in the prefrontal cortex (PFC) plays an important role in cognitive dysfunction in schizophrenia. Sub-chronic phencyclidine (scPCP) treatment produces cognitive impairments in rodents and ...
  • Mechanism of hydrogen-bonded complex formation between ibuprofen and nanocrystalline hydroxyapatite 

    Ryabenkova Y, Jadav N, Conte M et al (2017) Mechanism of hydrogen-bonded complex formation between ibuprofen and nanocrystalline hydroxyapatite. Langmuir. 33(12): 2965-2976.
    Nanocrystalline hydroxyapatite (nanoHA) is the main hard component of bone and has potential to be used to promote osseointegration of implants and to treat bone defects. Here, using active pharmaceutical ingredients (APIs) ...
  • Genetics of type 5 M protein of Streptococcus pyogenes 

    Kehoe MA, Miller L, Poirier TP et al (1987) Genetics of type 5 M protein of Streptococcus pyogenes. In: Ferretti JJ and Curtiss R III (Eds.) Streptococcal Genetics. Washington, US: ASM Publications: 112-116.
  • The mutagenic activity of ethylmethanesulphonate, benzidine and benzo[a]pyrene at the hprt locus of wild-type L5178Y mouse lymphoma cells 

    Kennelly JC, Clare CB, Campbell J et al (1990) The mutagenic activity of ethylmethanesulphonate, benzidine and benzo[a]pyrene at the hprt locus of wild-type L5178Y mouse lymphoma cells. Mutagenesis. 5(Supplement): 21-26.
    Ethylmethanesulphonate (EMS), benzidine (BZD) and benzo[a]pyrene (B[a]P) were assayed for ability to induce mutation at the hprt locus of wild-type L5178Y mouse lymphoma cells. EMS was assayed in the absence of metabolic ...
  • Multiple changes in cell wall antigens of isogenic mutants of Streptococcus mutans 

    Harrington DJ and Russell RRB (1993) Multiple changes in cell wall antigens of isogenic mutants of Streptococcus mutans. Journal of Bacteriology. 175(18): 5925-5933.
    Isogenic mutants of Streptococcus mutans LT11, deficient in the production of the wall-associated protein antigens A and B, were generated by recombinant DNA technology. The hydrophobicity, adherence, and aggregation of ...
  • Identification and characterisation of two extracellular proteases of Streptococcus mutans 

    Harrington DJ and Russell RRB (1994) Identification and characterisation of two extracellular proteases of Streptococcus mutans. FEMS Microbiology Letters. 121(2): 237-241.
    Streptococcus mutans was shown to produce two extracellular proteases capable of degrading both gelatin and collagen-like substrates. These enzymes have molecular masses of 52 and 50 kDa when analysed by SDS-PAGE. Both ...

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