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  • An Anatomically Customizable Computational Model Relating the Visual Field to the Optic Nerve Head in Individual Eyes 

    Denniss J, McKendrick AM and Turpin A (2012) An Anatomically Customizable Computational Model Relating the Visual Field to the Optic Nerve Head in Individual Eyes. Investigative Ophthalmology and Visual Science. 53(11): 6981-6990.
    To present a computational model mapping visual field (VF) locations to optic nerve head (ONH) sectors accounting for individual ocular anatomy, and to describe the effects of anatomical variability on maps produced. A ...
  • Estimation of Hemoglobin Levels in the Optic Nerve Head for Glaucoma Management 

    Denniss J (2013) Estimation of Hemoglobin Levels in the Optic Nerve Head for Glaucoma Management. Investigative Ophthalmology and Visual Science. 54(2): 1515.
  • Towards patient-tailored perimetry: automated perimetry can be improved by seeding procedures with patient-specific structural information 

    Denniss J, McKendrick AM and Turpin A (2013) Towards Patient-Tailored Perimetry: Automated Perimetry Can Be Improved by Seeding Procedures With Patient-Specific Structural Information. Translational Vision Science and Technology. 2(4): 3.
    To explore the performance of patient-specific prior information, for example, from structural imaging, in improving perimetric procedures. Computer simulation was used to determine the error distribution and presentation ...
  • Are patients with non-valvular atrial fibrillation involved in decision-making about oral anticoagulants? A literature review 

    Medlinskiene K, Petty D, Richardson S and Stirling K. (2018) Are patients with non-valvular atrial fibrillation involved in decision-making about oral anticoagulants? A literature review. [Conference poster abstract]. International Journal of Pharmacy Practice. 26 (Suppl. 1): 42-43.
    Patients with non-valvular atrial fibrillation (AF) requiring oral anticoagulants (OAC) for stroke prevention currently have a choice of five OACs. A systematic review was undertaken to explore if patients with AF requiring ...
  • MicroRNA‐21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells 

    Alshanwani AR, Riches-Suman K, O’Regan DJ et al (2018) MicroRNA-21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells. IUBMB Life. Article in Press.
    Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant ...
  • The temporal dynamics of Arc expression regulate cognitive flexibility 

    Wall MJ, Collins DR, Chery SL et al (2018) The temporal dynamics of Arc expression regulate cognitive flexibility. Neuron. Article in Press.
    Neuronal activity regulates the transcription and translation of the immediate-early gene Arc/Arg3.1, a key mediator of synaptic plasticity. Proteasomedependent degradation of Arc tightly limits its temporal expression, ...
  • United Kingdom: Brief overview of the health supply chain in the country 

    Breen L, Urban R and Zaman H (2018) United Kingdom: Brief overview of the health supply chain in the country. In: Pharmacists in the supply chain; the role of the medicines expert in ensuring quality and availability. The Hague, Netherlands; International Pharmceutical Federation (FIP) pp 58-62.
    The health supply chain within the United Kingdom follows a traditional model adopted by many countries globally. This is typically the sourcing of products from manufacturer to pharmacy (hospital and community) via ...
  • Segmental mobility studies of poly(N-isopropyl acrylamide) interactions with gold nanoparticles and its use as a thermally driven trapping system 

    Swift T, Rehman K, Surtees A et al (2018) Segmental mobility studies of poly(N-isopropyl acrylamide) interactions with gold nanoparticles and its use as a thermally driven trapping system. Macromolecular Rapid Communications. Article in Press.
    Thermal desolvation of poly(N‐isopropylacrylamide) (PNIPAM) in the presence of a low concentration of gold nanoparticles incorporates the nanoparticles resulting in suspended aggregates. By covalently incorporating <1% ...
  • Oral anticoagulants for stroke prevention in nonvalvular AF 

    Medlinskiene K and Petty D (2017) Oral anticoagulants for stroke prevention in non-valvular AF. Prescriber. 28(9): 37-43.
    Warfarin and direct oral anticoagulants (DOACs) have been shown to reduce the risk of stroke in patients with atrial fibrillation, yet many patients are still not being anticoagulated. This article discusses the barriers ...
  • Retrospective longitudinal study of patients and prescriber characteristics associated with new DOAC prescriptions in a CCG without restrictions to DOAC use 

    Medlinskiene K, Fay M and Petty D (2018) Retrospective longitudinal study of patients and prescriber characteristics associated with new DOAC prescriptions in a CCG without restrictions to DOAC use. International Journal of Pharmacy Practice. 26 (Suppl.1): 26-27.
    Direct oral anticoagulants (DOACs) uptake for stroke prevention in atrial fibrillation has been slow.[1] This study aimed to profile the prescribing of DOACs over three years to identify factors associated with DOAC ...
  • Why do people drive when they can’t see clearly? 

    Fylan F, Hughes A, Wood JM et al (2018) Why do people drive when they can't see clearly? Transportation Research Part F: Traffic Psychology and Behaviour. 56: 123-133.
    Purpose Refractive blur is associated with decreased hazard perception and impairments in driving performance, but little is known about why people who have spectacles to correct their distance vision drive with uncorrected ...
  • Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones 

    Errington RJ, Sadiq M, Cosentino L et al (2018) Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones. Bioorganic & Medicinal Chemistry Letters. 28(8): 1274-1277.
    Structural features from the anticancer prodrug nemorubicin (MMDX) and the DNA-binding molecule DRAQ5™ were used to prepare anthraquinone-based compounds, which were assessed for their potential to interrogate cytochrome ...
  • Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid 

    Pippione AC, Carnovale IM, Bonanni D et al (2018) Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. European Journal of Medicinal Chemistry. 150: 930-945.
    The aldo-keto reductase 1C3 (AKR1C3) isoform plays a vital role in the biosynthesis of androgens and is considered an attractive target in prostate cancer (PCa). No AKR1C3-targeted agent has to date been approved for ...
  • Durrington Walls and the Stonehenge Hidden Landscape Project 2010-2016 

    Gaffney V, Neubauer W, Garwood P et al (2018) Durrington Walls and the Stonehenge Hidden Landscape Project 2010-2016. Archaeological Prospection. Accepted for Publication.
    Since 2010 the Stonehenge Hidden Landscapes Project (SHLP) has undertaken extensive archaeological prospection across much of the landscape surrounding Stonehenge. These remote sensing and geophysical surveys have revealed ...
  • Determination of contamination by polycyclic aromatic hydrocarbons, and their mode of origin, in urban soils from Leeds (UK) 

    Hamed HAM, Hale WHG and Stern B (2018) Determination of contamination by polycyclic aromatic hydrocarbons, and their mode of origin, in urban soils from Leeds (UK). ISER - 347th International Conference on Chemical and Environmental Sciences (ICCES). 21-22 Apr 2018. Antalya, Turkey.
    This study aims to determine the concentration of 16 Polycyclic Aromatic Hydrocarbons (PAHs) in urban soils from Leeds in order to determine what the factors are controlling their distribution and abundances. Soil samples ...
  • Tristearin bilayers: structure of the aqueous interface and stability in the presence of surfactants 

    Hughes ZE and Walsh TR (2015) Tristearin bilayers: structure of the aqueous interface and stability in the presence of surfactants. RSC Advances. 5: 49933-49943.
    We report results of atomistic molecular dynamics simulations of an industrially-relevant, exemplar triacylglycerol (TAG), namely tristearin (TS), under aqueous conditions, at different temperatures and in the presence of ...
  • What makes a good graphene-binding peptide? Adsorption of amino acids and peptides at aqueous graphene interfaces 

    Hughes ZE and Walsh TR (2015) What makes a good graphene-binding peptide? Adsorption of amino acids and peptides at aqueous graphene interfaces. Journal of Materials Chemistry B. 3: 3211-3221.
    Investigation of the non-covalent interaction of biomolecules with aqueous graphene interfaces is a rapidly expanding area. However, reliable exploitation of these interfaces in many applications requires that the links ...
  • Computational chemistry for graphene-based energy applications: progress and challenges 

    Hughes ZE and Walsh TR (2015) Computational chemistry for graphene-based energy applications: progress and challenges. Nanoscale. 7: 6883-6908.
    Research in graphene-based energy materials is a rapidly growing area. Many graphene-based energy applications involve interfacial processes. To enable advances in the design of these energy materials, such that their ...
  • Peptide-mediated growth and dispersion of Au nanoparticles in water via sequence engineering 

    Nguyen MA, Hughes ZE, Liu Y et al (2018) Peptide-mediated growth and dispersion of Au nanoparticles in water via sequence engineering. The Journal of Physical Chemistry C. Accepted for Publication.
    The use of peptides to nucleate, grow, and stabilize nanoparticles in aqueous media via non-covalent interactions offers new possibilities for creating functional, water-dispersed inorganic/organic hybrid materials, ...
  • New class of hybrid materials for detection, capture, and "on-demand" release of carbon monoxide 

    Pitto-Barry A, Lupan A, Ellingford C et al (2018) New class of hybrid materials for detection, capture, and “on-demand” release of carbon monoxide. ACS Applied Materials & Interfaces. 10(16): 13693-13701.
    Carbon monoxide (CO) is both a substance hazardous to health and a side product of a number of industrial processes, such as methanol steam reforming and large-scale oxidation reactions. The separation of CO from nitrogen ...

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