Bradford Scholars is the University of Bradford online research archive. Access is free to anyone interested in research being conducted at Bradford. In the repository you will find a range of materials from journal articles and conference papers to research reports and theses.

Contact the repository team via openaccess@bradford.ac.uk with any queries about Open Access or how to deposit your research papers.

 


 

Shown below is a list of communities and the collections and sub-communities within them. Click on a name to view that community or collection home page.

  • Investigation to Identify the Influence of the Surface Energetics of the Dry Powder Formulations of Budesonide and Theophylline on Their Aerodynamic Dose Emission Characteristics.

    Assi, Khaled H.; Vangala, Venu R.; Jamal, Abdullateef J.A.M.A. (University of BradfordSchool of Pharmacy. Faculty of Life Sciences, 2022)
    Surface energetics play a key role in the delivery of a dry powder inhaler formulation into the lungs, as there must be a sufficient balance of adhesive and cohesive forces to allow optimal lung delivery. In this study, measuring the surface energies of a set of single drug and carrier (budesonide or theophylline with either mannitol or lactose) with different levels of surfactant using Inverse Gas Chromatography, and comparing them to their lung deposition performance using a Next Generation Impactor established a relationship between the two. A 1:10 mixing ratio of budesonide with either carrier was found to have the highest FPF. Coating the carriers with 0.05% sodium lauryl sulphate resulted in a further increase in the FPF when using either budesonide or theophylline as the API, and the same results were seen when a sonocrystallised version of the API was substituted for the micronised form. The calculated IGC values then showed that the highest performing formulations had the lowest dispersive energy and total free surface energy. Furthermore, a trend was observed in the work of adhesion (Wa) and work of cohesion (Wc) for each set of formulations depending on which API was chosen, where for the less polar drug (budesonide) a higher Wa/Wc ratio was associated with the highest formulation performance, and for the more polar drug (theophylline) a smaller Wa/Wc ratio was associated with the highest formulation performance, enabling the estimation of lung performance for a set of single drug and carrier using their surface energy data.
  • An Evaluation of Technological, Organizational and Environmental Determinants of Emerging Technologies Adoption Driving SMEs’ Competitive Advantage

    Sivarajah, Uthayasankar; Rana, Nripendra P.; Vincent, Charles; Dobre, Marius (University of BradfordSchool of Management. Faculty of Management, Law, and Social Sciences, 2022)
    This research evaluates the technological, organizational, and environmental determinants of emerging technologies adoption represented by Artificial Intelligence (AI) and Internet of Things (IoT) driving SMEs’ competitive advantage within a resource-based view (RBV) theoretical approach supported by the technological-organizational-environmental (TOE)-framework setting. Current literature on SMEs competitive advantage as outcome of emerging technologies in the technological, organisational, and environmental contexts presents models focused on these contexts individual components. There are no models in the literature to represent the TOE framework as an integrated structure with gradual levels of complexity, allowing for incremental evaluation of the business context in support of decision making towards emerging technologies adoption supporting the firm competitive advantage. This research gap is addressed with the introduction of a new concept, the IT resource-based renewal, underpinned by the RBV, and supported by the TOE framework for providing a holistic understanding of the SMEs strategic renewal decision through information technology. This is achieved through a complex measurement model with four level constructs, leading into a parsimonious structural model that evaluates the relationships between IT resource-based renewal, and emerging technologies adoption driving SMEs competitive advantage. The model confirms the positive association between the IT resource-based renewal and emerging technologies adoption, and between the IT resource-based renewal and SME competitive advantage for the SMEs managers model, with the SME owners model outcomes are found not being supportive towards emerging technologies adoption driving SME competitive advantage. As methodology, PLS-SEM is used for its capabilities of assessing complex paths among model variables. Analysis is done on three models, one for the full sample, with two subsequent ones for owners and managers, respectively, as SME decision makers, with data collected using a web-based survey in Canada, the UK, and the US, that has provided 510 usable answers. This research has a theoretical contribution represented by the introduction of the IT resource-based renewal concept, that integrates the RBV perspective and the TOE framework for supporting organization’s decision on emerging technologies adoption driving SMEs competitive advantage. As practical implications, this thesis provides SMEs with a reference framework on adopting emerging technologies, offering SME managers and owners a comprehensive model of hierarchical factors contributing to SMEs competitive advantage acquired as outcome of AI and IoT adoption. This research makes an original contribution to the enterprise management, information systems adoption, and SME competitive advantage literature, with an empirical approach that verifies a model of emerging technologies adoption determinants driving SMEs competitive advantage.
  • Historic settlement on Unst, Shetland. An holistic study of abandoned settlements on Unst, Shetland utilising historical archaeology and prospection approaches

    Bond, Julie M.; Gaffney, Christopher F.; Heron, Carl P.; Legg, Robert M. (University of BradfordSchool of Archaeological and Forensic Sciences. Faculty of Life Sciences, 2018)
    A holistic study of abandoned house sites on the island of Unst was conducted to address the extent to which perceptions of historic settlement on Shetland are supportable. These perceptions cast long lived nucleated settlement as the normative traditional form of historic settlement, and dispersed settlements as short-lived exceptions to this norm. Historic settlement, in these perceptions are argued to be static, which is not borne out in archaeological evidence. Issues associated with historic Shetland settlement models were identified to parallel traditional views of Scottish highland rural settlement, which cast the highland society as ahistoric and unchanging. Historical, archaeological and geographic evidence for settlement on Unst were used to assess the geographical distribution of historic settlement on the island. Two detailed case studies integrated archaeological prospection techniques with the historical, archaeological and landscape contexts to form new narratives for the field remains around two abandoned house sites. Assessment of the historical settlement of Unst highlighted a much greater degree of variation between the different evidence strands for the perceptions to truly represent the island’s historical settlement. Similarly, findings from the case studies highlighted a much greater degree of alterations to the field systems and enclosures associated with the settlements than would be anticipated. Alternative narratives with several phases were hypothesised for field remains of each case study.
  • The therapeutic/anti-carcinogenic effect of cord blood stem cells-derived exosomes in malignant melanoma

    Najafzadeh, Mojgan; Anderson, Diana; Isreb, Mohammad; Baumgartner, Adolf; Wright, Andrew; Naeem, Parisa (University of BradfordFaculty of Life Sciences, 2022)
    Malignant melanoma is an invasive type of skin cancer with high mortality rates, if not detected promptly. The mortality trends are generally linked to multiple dysplastic nevi, positive family history, genetic susceptibility and phenotypic features including fair skin, freckles, numerous atypical nevi, light coloured hair and eyes, inability to tan and prolonged exposure to ultraviolet radiation B (UVB). To date, the major anti-cancer therapeutics for melanoma include surgery, chemotherapy, radiotherapy, and immunotherapy. Recently, extracellular vesicles, especially exosomes, have been highlighted for their therapeutic benefits in numerous chronic diseases such as cancer. Exosomes display multifunctional properties, including inhibition of cancer cell proliferation and initiation of apoptosis. Hence, this study aimed to evaluate the genotoxicity and cytotoxicity of cord blood stem cell-derived (CBSC) exosomes on 6 samples of peripheral blood lymphocytes taken from healthy individuals and melanoma patients and on 3 samples of melanoma (CHL-1) cells. The limited number of samples was due to the time limitations and restrictions that were in place due to the COVID-19 pandemic. In this in vitro study, the optimal concentration of CBSC-derived exosomes (0, 100, 200, 300, 400 μg/ml protein at 24, 48 and 72h treatments) was confirmed by the CCK-8 assay. CBSC exosomes (300 μg/ml) were used to treat lymphocytes and CHL-1 cells in the Comet assay and evaluated using the real-time polymerase chain reaction (qPCR) and Western blotting (WB). The data of the CCK-8 and Comet assays illustrated that exosomes exerted genotoxic effects on CHL-1 cells (CCK-8 assay, ****p < 0.0001), (Comet assay, *p <0.05, **p < 0.01). However, the data portraying a reduction in the viability of lymphocytes needs further investigation as the number of samples was limited, therefore, further clarification is required. Importantly, no significant adverse effect was observed in healthy lymphocytes when treated with the same exosomes (p = ns). When further challenged with UVA+B radiation, the exosomes did not induce any genoprotective effect on ROS-induced CHL-1 cells, compared to the positive control (p = ns). Our data insinuates that the damage might be caused by inducing apoptosis. The anti-tumourigenic potential of exosomes was observed by activating the p53-mediated apoptotic pathway in CHL-1 cells, up-regulating p53, p21 and caspase 3 and down-regulating BCL-2 at mRNA (**p < 0.01, ***p <0.001, ****p <0.0001) and protein levels (*p < 0.05, **p <0.01). The potency of CBSC exosomes in inhibiting cancer progression in CHL-1 cells whilst causing no harm to the healthy lymphocytes makes it an ideal potential candidate for anti-cancer therapy. More samples are required to evaluate the therapeutic effect of exosomes on lymphocytes from cancer patients to fully understand their mechanism of action.
  • Regional economic inequalities; migration and community response, with special reference to Yugoslavia

    Singleton, Frederick B. (1979)
    After a general introduction to the problems of regional imbalance, this paper proceeds to an analysis of the background and causes of regional economic inequalities in Yugoslavia. Demographic factors are outlined with reference to Yugoslav statistical sources, and the policies being adopted for those areas defined as being in need of special assistance are examined. The author concludes by indicating some lessons to be drawn from Yugoslavia's experience of migration and especially of its workers abroad.

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