• Evaluation of bandwidth management technique using dynamic LSP tunnelling and LDP in MPLS for sustainable mobile wireless networks

  Mustapha, O.Z.; Hu, Yim Fun; Sheriff, Ray E.; Abd-Alhameed, Raed A.; Ali, M. (2020-03)

  Fairness in bandwidth resource allocation is highly significance to the advancement of the future generation mobile and wireless technologies. It is likely that restriction of bandwidth due to the employment of some scheduling scheme would not be an appropriate option for the future development of communication systems. However, there is need to consider an implementation that would lead to good network performance and avoid unguaranteed bandwidth delivery. This paper focusses on evaluating the performance of Bandwidth Allocation using Dynamic Label Switching Paths (LSPs) Tunnelling and Label Distribution Protocol (LDP) signalling in Multi-Protocol Label Switching (MPLS) network. This will make provision for bandwidth allocation and reservation possible. An appropriate bandwidth allocation would have a positive impact on throughput as well as the delay. The results of an IP (Internet Protocol) Network without MPLS enabled is compared with MPLS model network. Furthermore, implementation of dynamic and static LSPs models are presented with about 75% decrease in packet delay variation for dynamic LSP when compared from static LSP. In addition, the models of bandwidth estimation, bandwidth allocation, delay and jitter are provided. Performance metrics used in this respect for multimedia services (Voice and Video conferencing) confirm that the modified models are improved in comparison with the baseline, having highest throughput of about 51% increment, and packet delay variation decreases drastically.
• The mean–variance relation: A 24-hour story

  Wang, Wenzhao (2021-11)

  This paper investigates the mean-variance relation during different time periods within trading days. We reveal that there is a positive mean-variance relation when the stock market is closed (i.e., overnight), but the positive relation is distorted when the market is open (i.e., intraday). The evidence offers a new explanation for the weak risk-return tradeoff in stock markets.
• Institutional Investor Sentiment and the Mean-Variance Relationship: Global Evidence

  Wang, Wenzhao; Duxbury, D. (2021-11)

  I’m just writing to give you some information around the SAGE Premier Jisc Read and Publish agreement renewal for 2022. I’ve detailed some information below for 2022 on title changes, pricing and the renewal/opt-out process and to update you on the success we’ve seen with the OA aspect of the Jisc deal. The key points are: · 6.5% relief on 2021 prices due to Covid-19 is being maintained for 2022 so the total fee is not reverting to the pre-covid 2022 pricing this year. 2022 Fee (original) Covid-19 relief To pay for 2022 £80704 £5032 £75672 · No action is needed to renew for 2022, under the Jisc agreement. The price above will be automatically applied. · If you don’t want to be invoiced for 2022 you need to submit an opt-out to via the Jisc Helpdesk. by 30th November. · If you have any queries about VAT, you’ll need to contact the JISC Helpdesk due to the way the agreement is licensed. We are now three quarters of the way through the second year of the transformational Open Access agreement for Jisc members in the UK. We’ve continued to learn from members’ feedback and experiences as well as the data, so again, massive thank you to Jisc as well as the members for all the feedback, efforts and engagement over the last year. Increasing Open Access success: To date over 4500 articles from authors at English and Scottish universities have been made Open Access at no cost to the author under this agreement, saving UK universities funders and authors around £9.9million compared to paying for hybrid OA publishing. as well as over 300 articles published in a gold OA journal with a discounted APC. University of Bradford’s metrics are given below (1st Jan 2020 – 30th June 2021), we do expect the numbers to continue to rise. Published OA (Hybrid) Published Subscription APCs Waived Published OA (Gold) In Progress Total 2020 2021 (1/2 year) 2020 2021 (1/2 year) 2020 2021 (1/2 year) 2020 2021 (1/2 year) 2021 2020-2021 4 1 0 0 8800 2200 1 0 0 6 Title changes: Due to some last minute late changes to some society journals (society contracts so late changes aren’t under our absolute control), the final lists are still being completed, I’ll send these on in a separate email as soon as we have them finalised Renewal/Opt-Out Process: Your pricing has been confirmed at the reduced rate and passed to Jisc for 2022. Institutions wishing to opt-out for 2022 must place a cancellation order via the Jisc Helpdesk. no later than the 30th of November as detailed in the offer and 2020-2022 agreement. If you are renewing, there is no need to take any action. Any institutions who have not opted out via the Jisc website by the 30th of November will be invoiced by Jisc during December and access will continue uninterrupted through the new year.
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  What Are the Barriers and Enablers to the Implementation of Pharmacogenetic Testing in Mental Health Care Settings?

  Jameson, Adam; Fylan, Beth; Bristow, Greg C.; Sagoo, G.S.; Dalton, C.; Cardno, A.; Sohal, J.; McLean, Samantha L. (2021-09-22)

  In psychiatry, the selection of antipsychotics and antidepressants is generally led by a trial-and-error approach. The prescribing of these medications is complicated by sub-optimal efficacy and high rates of adverse drug reactions (ADRs). These both contribute to poor levels of adherence. Pharmacogenetics (PGx) considers how genetic variation can influence an individual’s response to a drug. Pharmacogenetic testing is a tool that could aid clinicians when selecting psychotropic medications, as part of a more personalized approach to prescribing. This may improve the use of and adherence to these medications. Yet to date, the implementation of PGx in mental health environments in the United Kingdom has been slow. This review aims to identify the current barriers and enablers to the implementation of PGx in psychiatry and determine how this can be applied to the uptake of PGx by NHS mental health providers. A systematic searching strategy was developed, and searches were carried out on the PsychInfo, EmBase, and PubMed databases, yielding 11 appropriate papers. Common barriers to the implementation of PGx included cost, concerns over incorporation into current workflow and a lack of knowledge about PGx; whilst frequent enablers included optimism that PGx could lead to precision medicine, reduce ADRs and become a more routine part of psychiatric clinical care. The uptake of PGx in psychiatric care settings in the NHS should consider and overcome these barriers, while looking to capitalize on the enablers identified in this review.
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  Psychological and social factors associated with coexisting frailty and cognitive impairment: A systematic review

  Ellwood, Alison; Mountain, Gail; Quinn, Catherine (2021)

  Those living with coexistent frailty and cognitive impairment are at risk of poorer health outcomes. Research often focuses on identifying biological factors. This review sought to identify the association psychological and social factors have with coexisting physical and cognitive decline. Six databases were systematically searched in July 2020. Studies included individuals aged 60 years or older identified as being both frail and cognitively impaired. A narrative synthesis examined patterns within the data. Nine studies were included, most employed a cross-sectional design. Depression was investigated by all nine studies, those with coexistent frailty and cognitive impairment had higher levels of depressive symptoms than peers. Findings were mixed on social factors, although broadly indicate lower education, living alone and lower material wealth were more frequent in those living with coexistent decline. Further research is needed to explore potentially modifiable psychological and social factors which could lead to the development of supportive interventions.

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