RSS 1.0Bradford Scholars is the University of Bradford online research archive. Access is free to anyone interested in research being conducted at Bradford. In the repository you will find a range of materials from journal articles and conference papers to research reports and theses.
Contact the repository team via openaccess@bradford.ac.uk with any queries about Open Access or how to deposit your research papers.
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Antitumour Imidazotetrazines: Past, Present... and Future?It is 40 years since the publication of the patent that announced the imidazotetrazines temozolomide and mitozolomide to the world and 30 since the discovery that they function as prodrugs of alkyldiazonium reactive intermediates. Temozolomide combined with radiation is established as the first-line treatment for glioma but despite the attentions of the inventors and others, further examples of this intriguing ring system have yet to enter the clinic.
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Challenges in using a Mixed-Method approach to explore the relationship between big data analytics capabilities and market performanceThis case study is based on a research study that examined the relationship between big data analytics capability and market performance. The study investigated the intervening role of disruptive business models and the contingency role of competitive intensity on the relationship between big data analytics capability and market performance using both qualitative and quantitative methods. This case-study will focus on the qualitative and quantitative methods utilised including NVivo and IBM SPSS to conduct qualitative analysis and quantitative analysis. You will learn the factors to consider when conducting a mixed-methods study and develop the ability to apply similar analytical techniques to your research context.
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Strategy Creation Behaviour and ‘Last Gasp’ Digitalisation as Predictors of Sales Performance and Cash FlowPurpose - Although recent literature has examined diverse measures adopted by SMEs to navigate the COVID-19 turbulence, there is a shortage of evidence on how crisis-time strategy creation behaviour and digitalization activities increase (1) sales and (2) cash flow. Thus, predicated on novel strategy creation perspective, this inquiry investigates the crisis behaviour, sales and cash flow performance of 528 SMEs in Morocco. Design/Methodology/Approach - Novel links between (1) aggregate wage cuts, (2) variable operating hours, (3) deferred payment to suppliers, (4) deferred payment to tax authorities and (5) sales performance are developed and tested. A further link between sales performance and cash flow is also examined and the analysis is performed using a non-linear structural equation modelling technique. Findings - While there is a significant association between the strategy creation behaviours and sales performance, only variable operating hours have a positive effect. Also, sales performance increases cash flow and this relationship is substantially strengthened by e-commerce digitalization and innovation. Originality/Value – Theoretically, this is one of the first inquiries to espouse the strategy creation view to explain SMEs’ crisis-time behaviour and digitalization. For practical use, to supplement Moroccan SMEs’ propensity to seek tax deferrals, it is argued that debt and equity support measures are also needed to boost sales performance and cash flow.
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Pharmacogenomics is the future of prescribing inpsychiatryPatients' pharmacogenetic data could be used to improve adherence to antipsychotic medication by increasing the likelihood of therapeutic response and reducing the prevalence of adverse drug reactions.