Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile which Involves Catalase.
Kauser, Sobia Westgate, Gillian E. Green, M.R. Tobin, Desmond J.
Kauser, Sobia
Westgate, Gillian E.
Green, M.R.
Tobin, Desmond J.
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2011
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Abstract
Canities or senile hair graying, a universally recognized sign of aging, remains unresolved in terms of physiological causes, although a strong genetic contribution is understood (Gunn et al., 2009). As the hair fiber continues to grow long after melanin production ceases, we suggest that melanocytes in the hair follicle may be more sensitive to the impact of chronological aging than are keratinocytes. Moreover, follicular melanocytes also age more markedly than those in the overlying epidermis. The hair follicle provides a unique opportunity to decouple the impact of age on two hair follicular tissue functions: hair formation and hair pigmentation. ... This study provides analysis of race, age, and anatomically matched cultures of adult human epidermal and hair follicle melanocytes (HFMs).
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Kauser S, Westgate GE, Green MR and Tobin DJ (2011) Human hair follicle and epidermal melanocytes exhibit striking differences in their aging profile which involves catalase [Letter to the editor]. Journal of Investigative Dermatology, 131(4): 979-82.
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