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    Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

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    Publication date
    2009
    Author
    Wood, John M.
    Decker, H.
    Hartmann, H.
    Chavan, Bhavan
    Rokos, Hartmut
    Spencer, J.D.
    Hasse, Sybille
    Thornton, M. Julie
    Shalbaf, Mohammad
    Paus, R.
    Schallreuter, Karin U.
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    Keyword
    Aging
    ; Catalase
    ; Hair color
    ; Hair follicle; Pathology
    ; Humans
    ; Hydrogen peroxide; Metabolism
    ; Methionine; Analogs; ; Derivatives; Deficiency
    ; Oxidative stress
    ; Reactive oxygen species
    ; Regeneration
    ; REF 2014
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    Abstract
    Senile graying of human hair has been the subject of intense research since ancient times. Reactive oxygen species have been implicated in hair follicle melanocyte apoptosis and DNA damage. Here we show for the first time by FT-Raman spectroscopy in vivo that human gray/white scalp hair shafts accumulate hydrogen peroxide (H(2)O(2)) in millimolar concentrations. Moreover, we demonstrate almost absent catalase and methionine sulfoxide reductase A and B protein expression via immunofluorescence and Western blot in association with a functional loss of methionine sulfoxide (Met-S=O) repair in the entire gray hair follicle. Accordingly, Met-S=O formation of Met residues, including Met 374 in the active site of tyrosinase, the key enzyme in melanogenesis, limits enzyme functionality, as evidenced by FT-Raman spectroscopy, computer simulation, and enzyme kinetics, which leads to gradual loss of hair color. Notably, under in vitro conditions, Met oxidation can be prevented by L-methionine. In summary, our data feed the long-voiced, but insufficiently proven, concept of H(2)O(2)-induced oxidative damage in the entire human hair follicle, inclusive of the hair shaft, as a key element in senile hair graying, which does not exclusively affect follicle melanocytes. This new insight could open new strategies for intervention and reversal of the hair graying process.
    URI
    http://hdl.handle.net/10454/6241
    Citation
    Wood JM, Decker H, Hartmann H et al (2009) Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair. FASEB Journal. 23(7): 2065-2075.
    Link to publisher’s version
    http://dx.doi.org/10.1096/fj.08-125435
    Type
    Article
    Collections
    Life Sciences Publications

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