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dc.contributor.authorGrant, Colin A.*
dc.contributor.authorTwigg, Peter C.*
dc.date.accessioned2014-04-28T10:41:14Z
dc.date.available2014-04-28T10:41:14Z
dc.date.issued2013
dc.identifier.citationGrant CA and Twigg PC (2013) Pseudostatic and dynamic nanomechanics of the tunica adventitia in elastic arteries using atomic force microscopy. ACS Nano. 7(1): 456-464.
dc.identifier.urihttp://hdl.handle.net/10454/5998
dc.descriptionNo
dc.description.abstractTunica adventitia, the outer layer of blood vessels, is an important structural feature, predominantly consisting of collagen fibrils. This study uses pseudostatic atomic force microscopy (AFM) nanoindentation at physiological conditions to show that the distribution of indentation modulus and viscous creep for the tunica adventitia of porcine aorta and pulmonary artery are distinct. Dynamic nanoindentation demonstrates that the viscous dissipation of the tunica adventitia of the aorta is greater than the pulmonary artery. We suggest that this mechanical property of the aortic adventitia is functionally advantageous due to the higher blood pressure within this vessel during the cardiac cycle. The effects on pulsatile deformation and dissipative energy losses are discussed.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1021/nn304508x
dc.subjectAdventitia physiology
dc.subject; Animals
dc.subject; Aorta physiology
dc.subject; Elastic modulus
dc.subject; Microscopy; Atomic force
dc.subject; Swine
dc.subject; Tensile strength
dc.subject; Viscosity
dc.subject; REF 2014
dc.titlePseudostatic and dynamic nanomechanics of the tunica adventitia in elastic arteries using atomic force microscopy
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository


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