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    Quantitative analysis of surfactant deposits on human skin by liquid chromatography electrospray ionisation tandem mass spectrometry.

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    Publication date
    2010
    Author
    Massey, Karen A.
    Snelling, Anna M.
    Nicolaou, Anna
    Keyword
    Sodium lauryl ether sulphate
    Lauramidopropyl betaine
    Human skin
    Surfactants
    Consumer wash products
    Cleansing agents
    Liquid Chromatography Electrospray Ionisation Tandem Mass Spectrometry (LC/ESI-MS/MS )
    Analysis
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Surfactants are commonly used as cleansing agents and yet there are concerns they may also have a role in skin irritation. Presently, the lack of suitable methods for quantitative and qualitative analysis of surfactant deposition on skin has hindered the in-depth investigation of such effects. Here, we report the application of reverse phase liquid chromatography electrospray ionisation mass spectrometry (LC/ESI-MS/MS) assays for two surfactants commonly used in consumer products, namely sodium lauryl ether sulphate (SLES) and laurylamidopropyl betaine (LAPB), to a baseline study aiming to assess deposition levels on human skin. The linearity of the assays was established at 3-20 ng, with coefficient of variation below 5%. Detection limits were 100 pg for LAPB and 1 ng for SLES; quantitation limits were 500 pg for LAPB and 2.5 ng for SLES. The baseline study was conducted using a panel of 40 healthy volunteers. Skin extract samples were taken in triplicate from forearms, using ethanol. SLES was detected on most volunteers, with 75% of them having SLES deposits in the range of 100-600 ng/cm2. LAPB was detected on the skin of all volunteers with 85% of them having deposit levels within the concentration range of 1-100 ng/cm2. These results demonstrate the extent to which commonly used surfactants remain on the skin during the day. The analytical methods reported here can be applied to the investigation of surfactants in relation to general skin condition and the development and optimisation of new consumer wash products.
    URI
    http://hdl.handle.net/10454/4574
    Citation
    Massey, K. A., Snelling, A. M. and Nicolaou, A. (2010). Quantitative analysis of surfactant deposits on human skin by liquid chromatography/electrospray ionisation tandem mass spectrometry. Rapid Communications in Mass Spectrometry, Vol. 24, No. 9, pp 1371-1376.
    Link to publisher’s version
    http://dx.doi.org/10.1002/rcm.4528
    Type
    Article
    Collections
    Life Sciences Publications

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