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    A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

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    Publication date
    2020-12
    Author
    Ngabonziza, J.C.S.
    Loiseau, C.
    Marceau, M.
    Jouet, A.
    Menardo, F.
    Tzfadia, O.
    Antoine, R.
    Niyigena, E.B.
    Mulders, W.
    Fissette, K.
    Diels, M.
    Gaudin, C.
    Duthoy, S.
    Ssengooba, W.
    André, E.
    Kaswa, M.K.
    Habimana, Y.M.
    Brites, D.
    Affolabi, D.
    Mazarati, J.B.
    de Jong, B.C.
    Rigouts, L.
    Gagneux, S.
    Meehan, Conor J.
    Supply, P.
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    Keyword
    Mycobacterium tuberculosis complex
    Africa
    African Great Lakes
    Lineage
    Rights
    © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/.
    Peer-Reviewed
    Yes
    Open Access status
    Gold
    
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    Abstract
    The human- and animal-adapted lineages of the Mycobacterium tuberculosis complex (MTBC) are thought to have expanded from a common progenitor in Africa. However, the molecular events that accompanied this emergence remain largely unknown. Here, we describe two MTBC strains isolated from patients with multidrug resistant tuberculosis, representing an as-yet-unknown lineage, named Lineage 8 (L8), seemingly restricted to the African Great Lakes region. Using genome-based phylogenetic reconstruction, we show that L8 is a sister clade to the known MTBC lineages. Comparison with other complete mycobacterial genomes indicate that the divergence of L8 preceded the loss of the cobF genome region - involved in the cobalamin/vitamin B12 synthesis - and gene interruptions in a subsequent common ancestor shared by all other known MTBC lineages. This discovery further supports an East African origin for the MTBC and provides additional molecular clues on the ancestral genome reduction associated with adaptation to a pathogenic lifestyle.
    URI
    http://hdl.handle.net/10454/18530
    Version
    Published version
    Citation
    Ngabonziza JCS, Loiseau C, Marceau M et al (2020) A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region. Nature Communications. 11: 2917.
    Link to publisher’s version
    https://doi.org/10.1038/s41467-020-16626-6
    Type
    Article
    Collections
    Life Sciences Publications

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