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Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals
Habas, Khaled S.A. Soldevila Barreda, Joan J. Azmanova, Maria Rafols, Laia Pitto-Barry, Anaïs Anderson, Diana Barry, Nicolas P.E.
Habas, Khaled S.A.
Soldevila Barreda, Joan J.
Azmanova, Maria
Rafols, Laia
Pitto-Barry, Anaïs
Anderson, Diana
Barry, Nicolas P.E.
Publication Date
2021-02
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© 2020 Wiley‐VCH GmbH. This is the peer-reviewed version of the following article: Habas K, Soldevila Barreda JJ, Azmanova M et al (2020) Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem. 16(4): 624-629, which has been published in final form at https://doi.org/10.1002/cmdc.202000672. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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2020-10-27
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Abstract
Electron‐deficient half‐sandwich complexes are a class of under‐studied organometallics with demonstrated potential as metallodrug candidates. The present study investigates the effect of two 16‐electron organoruthenium complexes ([( p‐ cym)Ru(benzene‐1,2‐dithiolato)] ( 1 ) and [( p ‐cym)Ru(maleonitriledithiolate)] ( 2 )) on the cell viability of non‐immortalised human lymphocytes from healthy individuals. The genotoxic effects of 1 and 2 in lymphocytes using the Comet and cytokinesis‐block micronucleus assays is also investigated. Gene expression studies were carried out on a panel of genes involved in apoptosis and DNA damage repair response. Results show that the two 16‐electron complexes do not have significant effect on the cell viability of human lymphocytes from healthy individuals. However, an increase in DNA damage is induced by both compounds, presumably through oxidative stress production.
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Habas K, Soldevila Barreda JJ, Azmanova M et al (2021) Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem. 16(4): 624-629.
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