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dc.contributor.authorHabas, Khaled S.A.
dc.contributor.authorSoldevila Barreda, Joan J.
dc.contributor.authorAzmanova, Maria
dc.contributor.authorRafols, Laia
dc.contributor.authorPitto-Barry, Anaïs
dc.contributor.authorAnderson, Diana
dc.contributor.authorBarry, Nicolas P.E.
dc.date.accessioned2020-10-29T09:38:55Z
dc.date.accessioned2020-11-09T16:26:28Z
dc.date.available2020-10-29T09:38:55Z
dc.date.available2020-11-09T16:26:28Z
dc.date.issued2020
dc.identifier.citationHabas K, Soldevila Barreda JJ, Azmanova M et al (2020) Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem. Accepted for Publication.en_US
dc.identifier.urihttp://hdl.handle.net/10454/18162
dc.descriptionYesen_US
dc.description.abstractElectron‐deficient half‐sandwich complexes are a class of under‐studied organometallics with demonstrated potential as metallodrug candidates. The present study investigates the effect of two 16‐electron organoruthenium complexes ([( p‐ cym)Ru(benzene‐1,2‐dithiolato)] ( 1 ) and [( p ‐cym)Ru(maleonitriledithiolate)] ( 2 )) on the cell viability of non‐immortalised human lymphocytes from healthy individuals. The genotoxic effects of 1 and 2 in lymphocytes using the Comet and cytokinesis‐block micronucleus assays is also investigated. Gene expression studies were carried out on a panel of genes involved in apoptosis and DNA damage repair response. Results show that the two 16‐electron complexes do not have significant effect on the cell viability of human lymphocytes from healthy individuals. However, an increase in DNA damage is induced by both compounds, presumably through oxidative stress production.en_US
dc.description.sponsorshipThis project was supported by the Royal Society (University Research Fellowship No. UF150295 to NPEB), the University of Bradford (RDF Award), and by the Academy of Medical Sciences/the Wellcome Trust/ the Government Department of Business, Energy and Industrial Strategy/ the British Heart Foundation Springboard Award [SBF003\1170 to NPEB].en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.1002/cmdc.202000672en_US
dc.rights© 2020 Wiley‐VCH GmbH. This is the peer reviewed version of the following article: Habas K, Soldevila Barreda JJ, Azmanova M et al (2020) Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem. Accepted for Publication, which has been published in final form at https://doi.org/10.1002/cmdc.202000672. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.subjectHalf-sandwich complexesen_US
dc.subjectElectron-deficient organometallicsen_US
dc.subjectBioinorganic chemistryen_US
dc.subjectLymphocytesen_US
dc.subjectAnticancer metallodrugsen_US
dc.titleEvaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individualsen_US
dc.status.refereedYesen_US
dc.date.Accepted2020-10-27
dc.date.application2020-10-29
dc.typeArticleen_US
dc.date.EndofEmbargo2021-10-30
dc.type.versionAccepted manuscripten_US
dc.description.publicnotesThe full-text of this article will be released for public view at the end of the publisher embargo on 30 Oct 2021.en_US
dc.date.updated2020-10-29T09:39:02Z
refterms.dateFOA2020-11-09T16:27:20Z


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