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    Fast, facile and solvent‐free dry melt synthesis of oxovanadium(IV) complexes: Simple design with high potency towards cancerous cells

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    Lord_et_al_Chemistry_A_European_Journal.pdf (850.3Kb)
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    Publication date
    2019-09
    Author
    Zegke, Markus
    Spencer, H.L.M.
    Lord, Rianne M.
    Keyword
    Bioinorganic chemistry
    Cancer
    Coordination compounds
    Solid-state synthesis
    Vanadium
    Antitumor agents
    Rights
    © 2019 Wiley This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at https://doi.org/10.1002/chem.201902441. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    Peer-Reviewed
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    Abstract
    A range of oxobis(phenyl‐1,3‐butanedione) vanadium(IV) complexes have been successfully synthesized from cheap starting materials and a simple and solvent‐free one‐pot dry‐melt reaction. This direct, straightforward, fast and alternative approach to inorganic synthesis has the potential for a wide range of applications. Analytical studies confirm their successful synthesis, purity and solid‐state coordination, and we report the complexes’ uses as potential drug candidates for the treatment of cancer. After a 24‐hour incubation of A549 lung carcinoma cells with the compounds, they reveal cytotoxicity values 11‐fold greater than cisplatin, and remain non‐toxic towards normal cell types. Additionally, the complexes are stable over a range of physiological pH values and show the potential for interactions with BSA.
    URI
    http://hdl.handle.net/10454/17232
    Version
    Accepted manuscript
    Citation
    Zegke M, Spencer HLM and Lord RM (2019) Fast, facile solvent-free dry-melt synthesis of oxovanadium(IV) complexes: Simple design with high potency towards cancerous cells. Chemistry: A European Journal. 25(53): 12275-12280.
    Link to publisher’s version
    https://doi.org/10.1002/chem.201902441
    Type
    Article
    Collections
    Life Sciences Publications

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