KeywordEthics; Licensing; UK National Health Service; Human Tissue Act; Human tissue; Tissue banking; Cost recovery
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AbstractFollowing legislative changes in 2004 and the establishment of the Human Tissue Authority, access to human tissues for biomedical research became a more onerous and tightly regulated process. Ethical Tissue was established to meet the growing demand for human tissues, using a process that provided ease of access by researchers whilst maintaining the highest ethical and regulatory standards. The establishment of a licensed research tissue bank entailed several key criteria covering ethical, legal, financial and logistical issues being met. A wide range of stakeholders, including the HTA, University of Bradford, flagged LREC, hospital trusts and clinical groups were also integral to the process.
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CitationAdams K and Martin S (2011) Ethical tissue: a not-for-profit model for human tissue supply. Cell and Tissue Banking. 12(1): 9-10.
Link to publisher’s versionhttps://doi.org/10.1007/s10561-010-9203-7
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The prediction of blood–tissue partitions, water–skin partitions and skin permeation for agrochemicalsAbraham, M.H.; Gola, J.M.R.; Ibrahim, A.; Acree, W.E. Jr.; Liu, Xiangli (2014-07)BACKGROUND: There is considerable interest in the blood–tissue distribution of agrochemicals, and a number of researchershave developed experimental methods for in vitro distribution. These methods involve the determination of saline–blood andsaline–tissue partitions; not only are they indirect, but they do not yield the required in vivo distribution.RESULTS: The authors set out equations for gas–tissue and blood–tissue distribution, for partition from water into skin andfor permeation from water through human skin. Together with Abraham descriptors for the agrochemicals, these equationscan be used to predict values for all of these processes. The present predictions compare favourably with experimental in vivoblood–tissue distribution where available. The predictions require no more than simple arithmetic.CONCLUSIONS: The present method represents a much easier and much more economic way of estimating blood–tissuepartitions than the method that uses saline–blood and saline–tissue partitions. It has the added advantages of yielding therequired in vivo partitions and being easily extended to the prediction of partition of agrochemicals from water into skin andpermeation from water through skin.