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    Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine

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    Paluch_Journal_of_Nanoparticle_Research.pdf (1.157Mb)
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    Publication date
    2017-06
    Author
    Dul, M.
    Paluch, Krzysztof J.
    Healy, A.M.
    Sasse, A.
    Tajber, L.
    Keyword
    Alginate; Protamine; Nanoparticles; Polyelectrolyte complex; Dynamic light scattering; Infrared spectroscopy
    Peer-Reviewed
    Yes
    
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    Abstract
    The aim of this work was to investigate the possibility of covalent cross-linker-free, polyelectrolyte complex formation at the nanoscale between alginic acid (as sodium alginate, ALG) and protamine (PROT). Optimisation of the self-assembly conditions was performed by varying the type of polymer used, pH of component solutions, mass mixing ratio of the components and the speed and order of component addition on the properties of complexes. Homogenous particles with nanometric sizes resulted when an aqueous dispersion of ALG was rapidly mixed with a solution of PROT. The polyelectrolyte complex between ALG and PROT was confirmed by infrared spectroscopy. To facilitate incorporation of drugs soluble at low pH, pH of ALG dispersion was decreased to 2; however, no nanoparticles (NPs) were formed upon complexation with PROT. Adjusting pH of PROT solution to 3 resulted in the formation of cationic or anionic NPs with a size range 70–300 nm. Colloidal stability of selected alginic acid low/PROT formulations was determined upon storage at room temperature and in liquid media at various pH. Physical stability of NPs correlated with the initial surface charge of particles and was time- and pH-dependent. Generally, better stability was observed for anionic NPs stored as native dispersions and in liquids covering a range of pH.
    URI
    http://hdl.handle.net/10454/12340
    Version
    Accepted Manuscript
    Citation
    Dul M, Paluch KJ, Healy AM et al (2017) Optimisation of the self-assembly process: production of stable, alginate-based polyelectrolyte nanocomplexes with protamine. Journal of Nanoparticle Research. 19:221.
    Link to publisher’s version
    http://dx.doi.org/10.1007/s11051-017-3901-z
    Type
    Article
    Collections
    Life Sciences Publications

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