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    Astrocytic Transporters in Alzheimer’s disease

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    Publication date
    2017
    Author
    Ugbode, Christopher I.
    Yuhan, H.
    Whalley, B.J.
    Peers, C.
    Rattray, Marcus
    Dallas, M.
    Keyword
    Astrocyte; Amyloid beta; Neurotransmitter transport; Azlheimer's disease
    Rights
    (c) 2017 The Authors. Full-text reproduced in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    Yes
    
    Metadata
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    Abstract
    Astrocytes play a fundamental role in maintaining the health and function of the central nervous system. Increasing evidence indicates that astrocytes undergo both cellular and molecular changes at an early stage in neurological diseases, including Alzheimer’s disease. These changes may reflect a change from a neuroprotective to a neurotoxic phenotype. Given the lack of current disease modifying therapies for Alzheimer’s disease, astrocytes have become an interesting and viable target for therapeutic intervention. The astrocyte transport system covers a diverse array of proteins involved in metabolic support, neurotransmission and synaptic architecture. Therefore, specific targeting of individual transporter families has the potential to suppress neurodegeneration, a characteristic hallmark of Alzheimer’s disease. A small number of the four hundred transporter superfamilies’ are expressed in astrocytes, with evidence highlighting a fraction of these are implicated in Alzheimer’s disease. Here we review the current evidence for six astrocytic transporter subfamilies involved in Alzheimer’s disease, as reported in both animal and human studies. This review confirms that astrocytes are indeed a viable target, highlights the complexities of studying astrocytes and provides future directives to exploit the potential of astrocytes in tackling Alzheimer’s disease.
    URI
    http://hdl.handle.net/10454/11004
    Version
    Accepted Manuscript
    Citation
    Ugbode C, Yuhan H, Whalley B et al (2017) Astrocytic Transporters in Alzheimer’s disease. Biochemical Journal. 474(3): 333-355.
    Link to publisher’s version
    https://doi.org/10.1042/BCJ20160505
    Type
    Article
    Collections
    Life Sciences Publications

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