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dc.contributor.authorIkolo, F.*
dc.contributor.authorZhang, M.*
dc.contributor.authorHarrington, Dean J.*
dc.contributor.authorRobinson, C.*
dc.contributor.authorWaller, A.S.*
dc.contributor.authorSutcliffe, I.C.*
dc.contributor.authorBlack, G.W.*
dc.date.accessioned2016-11-14T15:47:32Z
dc.date.available2016-11-14T15:47:32Z
dc.date.issued2015
dc.identifier.citationIkolo F, Zhang M, Harrison DJ et al (2015) Characterisation of SEQ0694 (PrsA/PrtM) of Streptococcus equi as a functional peptidyl-prolyl isomerase affecting multiple secreted protein substrates. Molecular BioSystems. 11(12): 3279-3286.en_US
dc.identifier.urihttp://hdl.handle.net/10454/10324
dc.descriptionYesen_US
dc.description.abstractPeptidyl-prolyl isomerase (PPIase) lipoproteins have been shown to influence the virulence of a number of Gram-positive bacterial human and animal pathogens, most likely through facilitating the folding of cell envelope and secreted virulence factors. Here, we used a proteomic approach to demonstrate that the Streptococcus equi PPIase SEQ0694 alters the production of multiple secreted proteins, including at least two putative virulence factors (FNE and IdeE2). We demonstrate also that, despite some unusual sequence features, recombinant SEQ0694 and its central parvulin domain are functional PPIases. These data add to our knowledge of the mechanisms by which lipoprotein PPIases contribute to the virulence of streptococcal pathogens.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1039/c5mb00543den_US
dc.rights© 2015 Royal Society of Chemistry. This is an Open Access article published under the Creative Commons CC-BY license (http://creativecommons.org/licenses/by/3.0/)en_US
dc.subjectStreptococcus equi; SEQ0694; Virulence; Human pathogens; Animal pathogens; Lipoprotein PPlasesen_US
dc.titleCharacterisation of SEQ0694 (PrsA/PrtM) of Streptococcus equi as a functional peptidyl-prolyl isomerase affecting multiple secreted protein substratesen_US
dc.status.refereedYesen_US
dc.date.Accepted2015-10-08
dc.date.application2015-10-08
dc.typeArticleen_US
dc.type.versionPublished versionen_US
refterms.dateFOA2018-07-27T01:42:57Z


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