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A mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing, and recycling properties for wound healing
Deng, X. Huang, B. Wang, Q. Wu, W. Coates, Philip D. Sefat, Farshid Lu, C. Zhang, W. Zhang, X.
Deng, X.
Huang, B.
Wang, Q.
Wu, W.
Coates, Philip D.
Sefat, Farshid
Lu, C.
Zhang, W.
Zhang, X.
Publication Date
2021-03
End of Embargo
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Rights
© 2020 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry and Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssuschemeng.0c06672.
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2021-01
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Abstract
Antibacterial hydrogels have been intensively
studied due to their wide practical potential in wound healing.
However, developing an antibacterial hydrogel that is able to
integrate with exceptional mechanical properties, cell affinity, and
adhesiveness will remain a major challenge. Herein, a novel
hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate−
dopamine (Alg-DA) chains to cross-link with the copolymer chains
of acrylamide and acrylic acid (PAM) via triple dynamic
noncovalent interactions, including coordination, electrostatic
interaction, and hydrogen bonding. The cationized nanofibrillated
cellulose (CATNFC), which was synthesized by the grafting of
long-chain quaternary ammonium salts onto nanofibrillated
cellulose (NFC), was utilized innovatively in the preparation of antibacterial hydrogels. Meanwhile, alginate-modified dopamine
(Alg-DA) was prepared from dopamine (DA) and alginate. Within the hydrogel, the catechol groups of Alg-DA provided a decent
fibroblast cell adhesion to the hydrogel. Additionally, the multitype cross-linking structure within the hydrogel rendered the
outstanding mechanical properties, self-healing ability, and recycling in pollution-free ways. The antibacterial test in vitro, cell
affinity, and wound healing proved that the as-prepared hydrogel was a potential material with all-around performances in both
preventing bacterial infection and promoting tissue regeneration during wound healing processes.
Version
Accepted manuscript
Citation
Deng X, Huang B, Wang Q et al (2021) Mussel-inspired antibacterial hydrogel with high cell affinity, toughness, self-healing and recycling properties for wound healing. ACS Sustainable Chemistry and Engineering. 9(8): 3070-3082.
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Article