A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6-19 years
Ashby, R.L. ; Ward, K.A. ; Roberts, S.A. ; Edwards, Lisa ; Mughal, M.Z. ; Adams, Jenny E.
Ashby, R.L.
Ward, K.A.
Roberts, S.A.
Edwards, Lisa
Mughal, M.Z.
Adams, Jenny E.
Publication Date
2009-08
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2008-11-04
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Abstract
Summary We have produced paediatric reference data for
forearm sites using the Stratec XCT-2000 peripheral
quantitative computed tomography scanner. These data are
intended for clinical and research use and will assist in the
interpretation of bone mineral density and bone geometric
parameters at the distal and mid-shaft radius in children and
young adults aged between 6–19 years.
Introduction Peripheral quantitative computed tomography
(pQCT) provides measurements of bone mineral content
(BMC), density (BMD) and bone geometry. There is a lack
of reference data available for the interpretation of pQCT
measurements in children and young adults. The aim of this
study was to provide reference data at the distal and midshaft
radius.
Methods pQCT was used to measure the 4% and 50% sites
of the non-dominant radius in a cohort of healthy white
Caucasian children and young adults aged between 5 and
25 years. The lambda, mu, sigma (LMS) technique was used
to produce gender-specific reference centile curves and LMS
tables for calculating individual standard deviations scores.
Results The study population consisted of 629 participants
(380 males). Reference centile curves were produced; total
and trabecular BMD for age (distal radius) and for age and
height, bone area (distal and mid-shaft radius), cortical area,
cortical thickness, BMC, axial moment of inertia, stress–
strain index and muscle area (mid-shaft radius).
Conclusions We present gender-specific databases for the
assessment of the distal and mid-shaft radius by pQCT.
These data can be used as control data for research studies
and allow the clinical interpretation of pQCT measurements
in children and young adults by age and height.
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Ashby RL, Ward KA, Roberts SA et al (2009) A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years. Osteoporosis International. 20(8): 1337-1346.
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