Publication

A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6-19 years

Ashby, R.L.
; 
Ward, K.A.
; 
Roberts, S.A.
; 
Edwards, Lisa
; 
Mughal, M.Z.
; 
Adams, Jenny E.
Publication Date
2009-08
End of Embargo
Supervisor
Keywords
Adolescent, Bone density, Bone development, Child, Reference values, Tomography, X-ray computed
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
2008-11-04
Institution
Department
Awarded
Embargo end date
Collections
Health Studies Publications
Show all metadata
Additional title
Abstract
Summary We have produced paediatric reference data for forearm sites using the Stratec XCT-2000 peripheral quantitative computed tomography scanner. These data are intended for clinical and research use and will assist in the interpretation of bone mineral density and bone geometric parameters at the distal and mid-shaft radius in children and young adults aged between 6–19 years. Introduction Peripheral quantitative computed tomography (pQCT) provides measurements of bone mineral content (BMC), density (BMD) and bone geometry. There is a lack of reference data available for the interpretation of pQCT measurements in children and young adults. The aim of this study was to provide reference data at the distal and midshaft radius. Methods pQCT was used to measure the 4% and 50% sites of the non-dominant radius in a cohort of healthy white Caucasian children and young adults aged between 5 and 25 years. The lambda, mu, sigma (LMS) technique was used to produce gender-specific reference centile curves and LMS tables for calculating individual standard deviations scores. Results The study population consisted of 629 participants (380 males). Reference centile curves were produced; total and trabecular BMD for age (distal radius) and for age and height, bone area (distal and mid-shaft radius), cortical area, cortical thickness, BMC, axial moment of inertia, stress– strain index and muscle area (mid-shaft radius). Conclusions We present gender-specific databases for the assessment of the distal and mid-shaft radius by pQCT. These data can be used as control data for research studies and allow the clinical interpretation of pQCT measurements in children and young adults by age and height.
URI
http://hdl.handle.net/10454/14542
Version
No full-text in the repository
Citation
Ashby RL, Ward KA, Roberts SA et al (2009) A reference database for the Stratec XCT-2000 peripheral quantitative computed tomography (pQCT) scanner in healthy children and young adults aged 6–19 years. Osteoporosis International. 20(8): 1337-1346.
Link to publisher’s version
Link to published version
Link to Version of Record
https://doi.org/10.1007/s00198-008-0800-2
Type
Article
Qualification name
Notes