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Interfacial cocrystallization using oily phase via liquid−liquid phase separation

Sajid, Asim
; 
Alsirawan, M.H.D. Bashir
; 
Seaton, Colin C.
; ; 
Pagire, Sudhir K.
; 
Vangala, Venu R.
; 
Kelly, Adrian L.
; 
Publication Date
2022-10
End of Embargo
Supervisor
Keywords
Crystallization, Crystals, Kinetic modeling, Solution chemistry, Solvents, Oily phase liquid–liquid phase separation (LLPS), Research Development Fund Publication Prize Award
Rights
© 2022 The Authors. Published by American Chemical Society. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/
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Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2022-09
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Department
Awarded
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Collections
Life Sciences Publications
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Abstract
Cocrystals consist of two molecules bonded together in a single crystal lattice giving rise to wide applications including improving solubility of poorly soluble pharmaceuticals. Cocrystallization reaction occurs in the oily phase of liquid–liquid phase separation (LLPS) after it is mixed with coformers. Indomethacin–saccharin cocrystal formation was monitored in situ, and the kinetics of crystallization were determined. The crystallization rates show that the process can be proposed to prevent unwanted oily phase formation during LLPS.
URI
http://hdl.handle.net/10454/19177
Version
Published version
Citation
Al-Hanafi Sajid A, Alsirawan MHDB, Seaton CC et al (2022) Interfacial cocrystallization using oily phase via liquid−liquid phase separation. Crystal, Growth & Design. 22(10): 5845-5851.
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Link to published version
Link to Version of Record
https://doi.org/10.1021/acs.cgd.2c00263
Type
Article
Qualification name
Notes
Research Development Fund Publication Prize Award winner, Sep 2022.