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Interfacial cocrystallization using oily phase via liquid−liquid phase separation

Sajid, Asim
Alsirawan, M.H.D. Bashir
Seaton, Colin C.
Pagire, Sudhir K.
Vangala, Venu R.
Kelly, Adrian L.
Publication Date
2022-10
End of Embargo
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Rights
© 2022 The Authors. Published by American Chemical Society. This work is licensed under a Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/
Peer-Reviewed
Yes
Open Access status
openAccess
Accepted for publication
2022-09
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Abstract
Cocrystals consist of two molecules bonded together in a single crystal lattice giving rise to wide applications including improving solubility of poorly soluble pharmaceuticals. Cocrystallization reaction occurs in the oily phase of liquid–liquid phase separation (LLPS) after it is mixed with coformers. Indomethacin–saccharin cocrystal formation was monitored in situ, and the kinetics of crystallization were determined. The crystallization rates show that the process can be proposed to prevent unwanted oily phase formation during LLPS.
Version
Published version
Citation
Al-Hanafi Sajid A, Alsirawan MHDB, Seaton CC et al (2022) Interfacial cocrystallization using oily phase via liquid−liquid phase separation. Crystal, Growth & Design. 22(10): 5845-5851.
Link to publisher’s version
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Article
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Notes
Research Development Fund Publication Prize Award winner, Sep 2022.