Fluorescent 7-Diethylaminocoumarin Pyrrolobenzodiazepine conjugates: Synthesis, DNA-Interaction, Cytotoxicity and Differential Cellular Localization.
Wells, G. Suggitt, Marie Coffils, M. Baig, M.A.H. Howard, P.W. Hartley, J.A. Jenkins, Terence C. Thurston, D.E.
Wells, G.
Suggitt, Marie
Coffils, M.
Baig, M.A.H.
Howard, P.W.
Hartley, J.A.
Jenkins, Terence C.
Thurston, D.E.
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2008
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Abstract
The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a class of DNA minor groove binding agents that react covalently with guanine bases, preferably at Pu-G-Pu sites. A series of three fluorescent PBD¿coumarin conjugates with different linker architectures has been synthesized to probe correlations between DNA binding affinity, cellular localization and cytotoxicity. The results show that the linker structure plays a critical role for all three parameters.
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A series of three fluorescent PBD¿coumarin conjugates with different linker architectures has been synthesized to probe correlations between DNA-binding affinity, cellular localization and cytotoxicity.
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Wells, G., Suggitt, M., Coffils, M., Baig, M.A.H., Howard, P.W., Loadman, P.M., Hartley, J.A., Jenkins, T.C. and Thurston, D.E. (2008). Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: Synthesis, DNA interaction, cytotoxicity and differential cellular localization. Bioorganic & Medicinal Chemistry Letters, Vol. 18, No. 6, pp. 2147-2151.
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