Mechanoenzymatic peptide and amide bond formation
Hernández, J.G. Ardila-Fierro, K.J. Crawford, Deborah E. James, S.L. Bolm, C.
Hernández, J.G.
Ardila-Fierro, K.J.
Crawford, Deborah E.
James, S.L.
Bolm, C.
Publication Date
2017-05
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2017-04-28
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Abstract
Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied by ball milling. Despite the high-energy mixing experienced inside the ball mill, the biocatalyst proved stable and highly efficient to catalyse the formation of α,α- and α,β-dipeptides. This strategy was further extended to the enzymatic acylation of amines by milling, and to the mechanosynthesis of a derivative of the valuable dipeptide L-alanyl-L-glutamine.
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Hernández JG, Ardila-Fierro KJ, Crawford DE et al (2017) Mechanoenzymatic peptide and amide bond formation. Green Chemistry. 19(11): 2620-2625.
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