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Comparison of coping, quality of life and psychosocial well-being in children and adult patients with vitiligo before and after treatment with pseudocatalase PC-KUS. A questionnaire-based investigation into social anxiety, helplessness, anxious-depressive mood, quality of life and depression before and after treatment with pseudocatalase PC-KUS depending on demographic characteristics and experiences.

KrĂ¼ger, Christian
Publication Date
2010-05-25T10:09:24Z
End of Embargo
Supervisor
Schallreuter, Karin U.
Keywords
Vitiligo, Quality of life, Social anxiety, Avoidance, Helplessness, Anxious / depressive mood, Depigmentation, Depression, Anxiety, Children, Adults, Pseudocatalase PC-KUS, Treatment
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Creative Commons License
The University of Bradford theses are licenced under a Creative Commons Licence.
Peer-Reviewed
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Accepted for publication
Institution
University of Bradford
Department
Division of Biomedical Sciences, School of Life Sciences.
Awarded
2009
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Abstract
Vitiligo is an idiopathic, non-contagious and often familial depigmentation disorder affecting both sexes equally. The mostly progressive and patchy loss of the inherited skin colour is not only a cosmetical problem, it has a profound impact on the patient¿s well-being. Stigmatisation and rejection often causes depression, self-consciousness, sexual problems and an impaired quality of life. To further substantiate earlier investigations and to introduce new aspects, we utilised the Dermatology Life Quality Index (DLQI), the Beck Depression Inventory (BDI) and the Adjustment to Chronic Skin Disorders Questionnaire (ACS) with its sub-scales on Social anxiety / avoidance, Helplessness and Anxious-depressive Mood in 422 patients and 55 healthy controls. We also included 103 children, their parents and 18 controls by using the Children¿s Dermatology Life Quality Index (CDLQI) and an adapted version of the ACS. We found that patients with vitiligo experience high levels of stigmatisation. They have an impaired quality of life and are more socially anxious / avoidant, helpless and (anxious-) depressive compared to healthy controls. The results correlate with disease severity, avoidant behaviour / hiding of vitiligo and the belief that psychological stress influences the disease. Female patients are generally more affected. Treatment with pseudocatalase PC-KUS improves quality of life and reduces anxious-depressive mood. Children also suffer from stigmatisation and an impaired quality of life. Parents are more socially anxious and helpless compared to the control group.
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http://hdl.handle.net/10454/4313
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Type
Thesis
Qualification name
PhD
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