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The role of photonics and natural curing agents of TGF-β1 in treatment of osteoarthritis

Ahmadi, E.D.
; 
Raja, Tehmeena I.
; 
Khaghani, Seyed A.
; 
Soon, C.F.
; 
Mozafari, M.
; ; 
Sefat, Farshid
Publication Date
2018
End of Embargo
Supervisor
Keywords
TGF- β1, Cytokines, Osteoarthritis, Photonics, Carbon nanotubes, Quantum dots, Photodynamic therapy
Rights
© 2018 Elsevier. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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Yes
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Accepted for publication
2018
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Engineering and Digital Technology Publications
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Abstract
Osteoarthritis (OA) is a degenerative disease leading to the breakdown of the hyaline cartilage between a varieties of diarthrodial joints such as the knee joint, carpals of the wrist and etc. When the cartilage is affected by trauma or wear and tear, Osteolysis may occur; broken debris of cartilage found within the synovial fluid may be recognised as a pathogen and therefore, the body’s autoimmune response will directly target the cartilage for destruction. Cytokines are proteins/peptides of glycoproteins that are secreted by cells and are involved in interaction and communication between cells. Transforming Growth Factors Beta 1 (TGF-β1) is one of well-known cytokines and had shown many effects on cellular biology including simulation or inhibition of cell proliferation, differentiation, production of extracellular matrix (ECM), remodelling, and producing both hormones and growth factors. On the other hand, Photonics recently play an important role for treatment of OA. The main aim of this review article is to investigate the effect of TGF-β1 in treatment of OA. Other important aim of this work is to explore the broad applications of optics and photonics in biomedical applications including treatment of OA. Biomedical applications of photonics have broad aspects including laser, carbon nanotubes (CNTs), quantum dots (QDs) and graphene and photodynamic therapy (PDT) which discussed in this review paper.
URI
http://hdl.handle.net/10454/16989
Version
Accepted manuscript
Citation
Ahmadi ED, Raja TI, Khaghani SA et al (2018) The role of photonics and natural curing agents of TGF-β1 in treatment of osteoarthritis. Materials Today: Proceedings. 5(7) Part 3: 15540-15549.
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https://doi.org/10.1016/j.matpr.2018.04.161
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Article
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