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Ex vivo rabbit and human corneas as models for bacterial and fungal keratitis
Pinnock, A. Shivshetty, N. Roy, S. Rimmer, Stephen Douglas, I. MacNeil, S. Gary, P.
Pinnock, A.
Shivshetty, N.
Roy, S.
Rimmer, Stephen
Douglas, I.
MacNeil, S.
Gary, P.
Publication Date
2017
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© 2017 The Authors. This is an Open Access article distributed under the
Creative Commons CC-BY license (http://creativecommons.org/licenses/by/4.0/)
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Yes
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openAccess
Accepted for publication
31/10/2016
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Abstract
In the study of microbial keratitis, in vivo animal models often require a large number of animals, and in vitro monolayer cell culture does not maintain the three-dimensional structure of the tissues or cell-to-cell communication of in vivo models. Here, we propose reproducible ex vivo models of single- and dual-infection keratitis as an alternative to in vivo and in vitro models.
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Published version
Citation
Pinnock A, Shivshetty N, Roy S et al (2017) Ex vivo rabbit and human corneas as models
for bacterial and fungal keratitis. Graeve’s Archive for Clinical and Experimental Ophthalmology.
255(2): 333-342.
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Article