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Impact of process variables on the micromeritic and physicochemical properties of spray-dried porous microparticles, part I: introduction of a new morphology classification system
Paluch, Krzysztof J. Tajber, L. Corrigan, O.I. Healy, A.M.
Paluch, Krzysztof J.
Tajber, L.
Corrigan, O.I.
Healy, A.M.
Publication Date
2012-11
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© 2012 Wiley
This is the peer reviewed version of the following article: Paluch KJ, Tajber L, Corrigan OI et al
(2012) Impact of process variables on the micromeritic and physicochemical properties of spraydried
porous microparticles, part I: introduction of a new morphology classification system.
Journal of Pharmacy and Pharmacology. 64(11): 1570-1582. , which has been published in final
form at http://dx.doi.org/10.1111/j.2042-7158.2012.01539.x. This article may be used for noncommercial
purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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2012-04-17
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Abstract
Objectives This work investigated the impact of spray drying variables such as feedconcentration, solvent composition and the drying mode, on the micromeriticproperties of chlorothiazide sodium (CTZNa) and chlorothiazide potassium(CTZK).Methods Microparticles were prepared by spray drying and characterised usingthermal analysis, helium pycnometry, laser diffraction, specific surface area analysisand scanning electron microscopy.Key findings Microparticles produced under different process conditions pre-sented several types of morphology.To systematise the description of morphology ofmicroparticles, a novel morphology classification system was introduced. The shapeof the microparticles was described as spherical (1) or irregular (2) and the surfacewas classified as smooth (A) or crumpled (B). Three classes of morphology of micro-particles were discerned visually: class I, non-porous; classes II and III, comprisingdiffering types of porosity characteristics. The interior was categorised as solid/continuous (a), hollow (b), unknown (g) and hollow with microparticulate content(d). Nanoporous microparticles of CTZNa and CTZK, produced without recircula-tion of the drying gas, had the largest specific surface area of 72.3 and 90.2 m2/g,respectively, and presented morphology of class 1BIIIa.Conclusions Alteration of spray drying process variables, particularly solvent com-position and feed concentration can have a significant effect on the morphology ofspray dried microparticulate products. Morphology of spray dried particles may beusefully described using the morphology classification system.
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Citation
Paluch KJ, Tajber L, Corrigan OI et al (2012) Impact of process variables on the
micromeritic and physicochemical properties of spray-dried porous microparticles, part I:
introduction of a new morphology classification system. Journal of Pharmacy and Pharmacology.
64(11): 1570-1582.
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Article