In vitro and ex vivo examination of topical Pomiferin treatment.
Gruber, J.V. Holtz, R. Tobin, Desmond J.
Gruber, J.V.
Holtz, R.
Tobin, Desmond J.
Publication Date
2014
End of Embargo
Supervisor
Rights
Peer-Reviewed
Yes
Open Access status
closedAccess
Accepted for publication
Institution
Department
Awarded
Embargo end date
Collections
Additional title
Abstract
Pomiferin is a unique, prenylated isoflavonoid that can be isolated and purified from the fruits of Maclura pomifera (Osage Orange). The molecule typically is isolated with a small amount of a molecule called Osajin which is structurally similar to Pomiferin but lacks an aromatic hydroxyl group. As a consequence, Osajin has been shown to be a less effective antioxidant than Pomiferin. In vitro studies on Normal Human Dermal Fibroblasts demonstrate that Pomiferin is a potent extracellular matrix protein stimulant, showing increases in collagen, elastin and fibrillin expression comparable or superior to equivalent concentrations of retinol. Ex vivo hair follicle assays demonstrate comparable effects on expression of collagen and
elastin at Pomiferin concentrations in the range of 0.05–5 ppm. Taken together, the results from the two assays conducted on different models indicate that Pomiferin may be a very interesting ingredient for topical skin and scalp treatments where modulation of the expression of extracellular matrix proteins is important.
Version
No full-text in the repository
Citation
Gruber, J.V., Holtz, R., Sikkink, S.K., Tobin, D.J., (2014) In vitro and ex vivo examination of topical Pomiferin treatments. Fitoterapia, 94:164-71.
Link to publisher’s version
Link to published version
Link to Version of Record
Type
Article