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    Antibiotic functionalised polymers reduce bacterial biofilm and bioburden in a simulated infection of the cornea

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    Swift_Biomaterials_Science_Final.pdf (1.565Mb)
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    Publication date
    2018
    Author
    Doroshenko, N.
    Rimmer, Stephen
    Hoskins, Richard
    Garg, P.
    Swift, Thomas
    Spencer, Hannah L.M.
    Lord, Rianne M.
    Katsikogianni, Maria G.
    Pownall, D.
    MacNeil, S.
    Douglas, C.W.I.
    Shepherd, J.
    Show allShow less
    Keyword
    Microbial keratitis
    Cornea
    Corneal trauma
    Antimicrobial therapy
    Rights
    © The Royal Society of Chemistry 2018. Open Access article. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    Microbial keratitis can arise from penetrating injuries to the cornea. Corneal trauma promotes bacterial attachment and biofilm growth, which decrease the effectiveness of antimicrobials against microbial keratitis. Improved therapeutic efficacy can be achieved by reducing microbial burden prior to antimicrobial therapy. This paper assesses a highly-branched poly(N-isopropyl acrylamide) with vancomycin end groups (HB-PNIPAM-van), for reducing bacterial attachment and biofilm formation. The polymer lacked antimicrobial activity against Staphylococcus aureus, but significantly inhibited biofilm formation (p = 0.0008) on plastic. Furthermore, pre-incubation of S. aureus cells with HB-PNIPAM-van reduced cell attachment by 50% and application of HB-PNIPAM-van to infected ex vivo rabbit corneas caused a 1-log reduction in bacterial recovery, compared to controls (p = 0.002). In conclusion, HB-PNIPAM-van may be a useful adjunct to antimicrobial therapy in the treatment of corneal infections.
    URI
    http://hdl.handle.net/10454/16402
    Version
    Published version
    Citation
    Doroshenko N, Rimmer S, Hoskins R et al (2018) Antibiotic functionalised polymers reduce bacterial biofilm and bioburden in a simulated infection of the cornea. Biomaterials Science. 6(8): 2101-2109.
    Link to publisher’s version
    http://dx.doi.org/10.1039/C8BM00201K
    Type
    Article
    Collections
    Life Sciences Publications

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