Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents
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06/08/2014Peer-Reviewed
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The solution-mediated polymorphic transformation from Form II to Form III 2-oxo-1-pyrrolidine acetamide (piracetam) was investigated in seven organic solvents over the temperature range of 5–50 °C. The transformation rate increased as a function of temperature, agitation, and the solubility of piracetam in the host solvent. However, this trend was reversed in 2-propanol. Molecular modeling demonstrated that 2-propanol forms interactions with piracetam molecules in solution stronger than those formed by other solvents, thereby retarding the nucleation and growth of FIII(6.525) during the transformation in this solvent.Version
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Maher A, Corker DM, Seaton CC et al (2014) Solution-Mediated Polymorphic Transformation: Form II to Form III Piracetam in Organic Solvents. Crystal Growth and Design. 14(8): 3967-3974.Link to Version of Record
https://doi.org/10.1021/cg500565uType
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.1021/cg500565u