De Paoli, M.Perco, P.Mühlberger, I.Lukas, A.Pandha, H.S.Morgan, RichardFeng, G.J.Marquette, C.2016-10-122016-10-1231/07/2015De Paoli M, Perco P, Mühlberger I et al. (2015) Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic. Biomarkers. 20(5): 328-337.http://hdl.handle.net/10454/9897YesContext: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer. Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer. Materials and methods: Urinary biomarkers concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis. Results: A 5-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set. Discussion and conclusion: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.en© 2015 Taylor & Francis. This is an Author's Original Manuscript of an article published by Taylor & Francis in Biomarkers on 31 Jul 2015, available online at http://www.tandfonline.com/10.3109/1354750X.2015.1068867BiomarkersBladder cancerInvasivenessRecurrenceArticlehttps://doi.org/10.3109/1354750X.2015.1068867Unspecified