Kulkarni, Chaitrali S.Kelly, Adrian L.Gough, TimJadhav, V.Singh, K.Paradkar, Anant R2017-10-252017-10-252017-11Kulkarni C, Kelly AL, Gough T et al (2017) Application of hot melt extrusion for improving bioavailability of artemisinin a thermolabile drug. Drug Development and Industrial Pharmacy. 44(2): 206-214.http://hdl.handle.net/10454/13552YesHot melt extrusion has been used to produce a solid dispersion of the thermolabile drug artemisinin. Formulation and process conditions were optimised prior to evaluation of dissolution and biopharmaceutical performance. Soluplus®, a low Tg amphiphilic polymer especially designed for solid dispersions enabled melt extrusion at 110ºC although some drug-polymer incompatibility was observed. Addition of 5% citric acid as a pH modifier was found to suppress the degradation. The area under plasma concentration time curve (AUC0-24hr) and peak plasma concentration (Cmax) were four times higher for the modified solid dispersion compared to that of pure artemisinin.en© 2017 Informa UK Limited, trading as Taylor & Francis Group. This is an Author's Original Manuscript of an article published by Taylor & Francis in Drug Development and Industrial Pharmacy on 16-11-2017 available online at http://www.tandfonline.com/10.1080/03639045.2017.1386200Thermolabile drugArtemisininSoluplus®CompatibilityBioavailabilityExtrusionArticlehttps://doi.org/10.1080/03639045.2017.1386200Unspecified