Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Santos, Ana R.N.Sheldrake, Helen M.Ibrahim, Ali I.M.Danta, Chhanda C.Bonanni, D.Daga, M.Oliaro-Bosso, s.Boschi, D.Lolli, M.L.Pors, Klaus2019-09-042019-09-242019-09-042019-09-242019-01Santos ARN, Sheldrake HM, Ibrahim AIM et al (2019) Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity. MedChemComm. 10(8): 1476-1480.RMSID:212517892http://hdl.handle.net/10454/17252YesTetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3.en(c) 2019 RSC. Full-text reproduced in accordance with the publisher's self-archiving policy.TetrahydroisoquinolineTHIQExploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinityArticlehttps://doi.org/10.1039/C9MD00201DUnspecified2019-09-04