Grossjohann, C.Serrano, D.R.Paluch, Krzysztof J.O'Connell, P.Vella-Zarb, L.Manesiotis, P.McCabe, T.Tajber, L.Corrigan, O.I.Healy, A.M.2017-11-082017-11-082015-04Grossjohann C, Serrano DR, Paluch KJ et al (2015) Polymorphism in sulfadimidine/4- aminosalicylic acid cocrystals: solid-state characterization and physicochemical properties. Journal of Pharmaceutical Sciences. 104(4): 1385-1398.http://hdl.handle.net/10454/13701YesPolymorphism of crystalline drugs is a common phenomenon. However, the number of reported polymorphic cocrystals is very limited. In this work, the synthesis and solid state characterisation of a polymorphic cocrystal composed of sulfadimidine (SD) and 4- aminosalicylic acid (4-ASA) is reported for the first time. By liquid-assisted milling, the SD:4-ASA 1:1 form I cocrystal, the structure of which has been previously reported, was formed. By spray drying, a new polymorphic form (form II) of the SD:4-ASA 1:1 cocrystal was discovered which could also be obtained by solvent evaporation from ethanol and acetone. Structure determination of the form II cocrystal was calculated using high resolution X-ray powder diffraction. The solubility of the SD:4-ASA 1:1 cocrystal was dependent on the pH and predicted by a model established for a two amphoteric component cocrystal. The form I cocrystal was found to be thermodynamically more stable in aqueous solution than form II, which showed transformation to form I. Dissolution studies revealed that the dissolution rate of SD from both cocrystals was enhanced when compared to a physical equimolar mixture and pure SD.en© 2015 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license.PolymorphismSulfadimidine4-aminosalicylic acidCocrystalsSpray dryingMillingArticlehttps://doi.org/10.1002/jps.24345CC-BY-NC-ND