Zhang, K.Xu, M.Su, J.Sun, Z.Li, Y.Zhang, W.Hou, J.Shang, LijunCui, H.2016-11-232016-11-232014Zhang K, Xu M, Su J et al (2014) Characterization and identification of the integrin family in silkworm, Bombyx mori. Gene. 549: 149-155.http://hdl.handle.net/10454/10480YesAs an important economic insect, Bombyx mori is also a useful model organism for lepidopteran insect. Integrins are evolutionarily conserved fromsponges to humans, and play vital roles inmany physiological and pathological processes. To explore their diverse functions of integrins in insect, eleven integrins including sixα and five β subunitswere cloned and characterized fromsilkworm. Our results showed that integrins fromsilkwormown more family members compared to other invertebrates. Among those α subunits, integrins α1, α2, and the other four subunits belong to PS1, PS2, and PS3 groups, respectively. The β subunits mainly gather in the insect βν group except the β1 subunit which belongs to the insect β group. Expression profiles demonstrated that the integrins exhibited distinct patterns, but were mainly expressed in hemocytes. α1 and β2 subunits are the predominant ones either in the embryogenesis or larva stages. Interestingly, integrins were significantly up-regulated after stimulated by 20-hydroxyecdysone (20-E) in vivo. These results indicate that integrins performdiverse functions in hemocytes of silkworm. Overall, our results provide a newinsight into the functional and evolutionary features of integrins.en© 2014 Elsevier. Reproduced in accordance with the publisher's selfarchiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Bombyx moriIntegrin familyEvolutionary analysisExpression patternArticlehttps://doi.org/10.1016/j.gene.2014.07.060CC-BY-NC-ND