Nicolaou, Anna2012-04-302012-04-302012Nicolaou, A. (2012). Eicosanoids in skin inflammation. Prostaglandins, Leukotrienes and Essential Fatty Acids. Article in Press. DOI: http://dx.doi.org/10.1016/j.plefa.2012.03.009http://hdl.handle.net/10454/5424YesEicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and inflammatory and allergic disorders, including psoriasis and atopic dermatitis. This review article discusses biochemical aspects related to cutaneous eicosanoid metabolism, the contribution of these potent autacoids to skin inflammation and related conditions, and considers the importance of nutritional supplementation with bioactives such as omega-3 and omega-6 polyunsaturated fatty acids and plant-derived antioxidants as means of addressing skin health issues.en© 2012 Elsevier. Reproduced in accordance with the publisher's self-archiving policy.SkinEicosanoidsPolyunsaturated Fatty AcidsInflammationHuman skinCutaneous eicosanoid metabolismArticlehttps://doi.org/10.1016/j.plefa.2012.03.009Unspecified