Investigation of cytochrome p450 isoforms 1A1, 1B1 and 2W1 as targets for therapeutic intervention in head and neck cancer. Probing CYP1A1, 1B1 and 2W1 activity with duocarmycin bioprecursors

Patterson, Laurence H.McCaul, JimPors, KlausPresa, Daniela2020-11-182020-11-182018http://hdl.handle.net/10454/18171en<a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><img alt="Creative Commons License" style="border-width:0" src="http://i.creativecommons.org/l/by-nc-nd/3.0/88x31.png" /></a><br />The University of Bradford theses are licenced under a <a rel="license" href="http://creativecommons.org/licenses/by-nc-nd/3.0/">Creative Commons Licence</a>.Cytochrome P450 (CYP)CYP1A1CYP1B1CYP2W1Head and Neck Cancer (HNC)DuocarmycinProdrugBioprecursorDNA damageTherapeutic interventionInvestigation of cytochrome p450 isoforms 1A1, 1B1 and 2W1 as targets for therapeutic intervention in head and neck cancer. Probing CYP1A1, 1B1 and 2W1 activity with duocarmycin bioprecursorsdoctoral