Process safety has drawn increasing attention in recent years and has been investigated from different perspectives, such as quantitative risk analysis, consequence modeling, and regulations. However, rare attempts have been made to focus on inherent safety design assessment, despite being the most cost-effective safety tactic and its vital role in sustainable development and safe operation of process infrastructure. Accordingly, the present research proposed a knowledge-driven model to assess inherent safety in process infrastructure under uncertainty. We first developed a holistic taxonomy of contributing factors into inherent safety design considering chemical, reaction, process, equipment, human factors, and organizational concerns associated with process plants. Then, we used subject matter experts, content validity ratio (CVR), and content validity index (CVI) to validate the taxonomy and data collection tools. We then employed a fuzzy inference system and the Extent Analysis (EA) method for knowledge acquisition under uncertainty. We tested the proposed model on a steam methane-reforming plant that produces hydrogen as renewable energy. The findings revealed the most contributing factors and indicators to improve the inherent safety design in the studied plant and effectively support the decision-making process to assign proper safety countermeasures.

Introduction: Children are at a higher risk of succumbing to diarrhoea. Zimbabwe remains one of the countries topping in terms of morbidity and mortality due to diarrhoea diseases among under-fives. This study aims to determine factors affecting diarrhoea among under-five children in Zimbabwe. Methodology: A systematic review was executed based on searches from six databases. All types of studies published between 2018 and 2022 in English about diarrhoea disease and among children under the age of five in Zimbabwe were included. Seventeen articles met the requirements of this study. All the data was inputted onto a data extraction sheet and thematic analysis was carried out on the study outcomes to identify themes. Results: Diarrhoea risk factors can be categorized into two main themes; modifiable and non-modifiable diarrhoea risk factors. Under the modifiable risk factors are four subthemes: environmental, socio-economic, behavioural, and modifiable biological diarrhoea risk factors. Under the non-modifiable risk factors are two sub-themes: age and gender. For any Water, Hygiene and Sanitation (WASH) intervention to succeed, these risk factors should be present at optimum. If any of the factors is not optimally present, WASH interventions must concurrently address the risk factor or else the intervention is predestined to fail. Conclusion: WASH remains an important issue in Zimbabwe as a tool to improve the lives of children under five years old. There is a necessity to investigate why certain interventions work well in other low-income countries and not Zimbabwe. All WASH interventions must make a thorough baseline assessment of conditions present on the ground to ensure the success of interventions.

Poloxamers or Pluronics®-based nanogels are one of the most used matrices for developing delivery systems. Due to their thermoresponsive and flexible mechanical properties, they allowed the incorporation of several molecules including drugs, biomacromolecules, lipid-derivatives, polymers, and metallic, polymeric, or lipid nanocarriers. The thermogelling mechanism is driven by micelles formation and their self-assembly as phase organizations (lamellar, hexagonal, cubic) in response to microenvironmental conditions such as temperature, osmolarity, and additives incorporated. Then, different biophysical techniques have been used for investigating those structural transitions from the mechanisms to the preferential component’s orientation and organization. Since the design of PL-based pharmaceutical formulations is driven by the choice of the polymer type, considering its physico-chemical properties, it is also relevant to highlight that factors inherent to the polymeric matrix can be strongly influenced by the presence of additives and how they are able to determine the nanogels biopharmaceuticals properties such as bioadhesion, drug loading, surface interaction behavior, dissolution, and release rate control. In this review, we discuss the general applicability of three of the main biophysical techniques used to characterize those systems, scattering techniques (small-angle X-ray and neutron scattering), rheology and Fourier transform infrared absorption spectroscopy (FTIR), connecting their supramolecular structure and insights for formulating effective therapeutic delivery systems.

Isaiah Berlin’s doctrine of objective pluralism has been criticised as amounting in fact to ethical and political relativism. Berlin has relied on two arguments in attempting to refute this charge, those from common intelligibility and from shared values. I propose that the former argument alone is sufficient to refute relativism, whilst the latter argument leads not to pluralism but to a broad or narrow monism, depending on the number of shared values, since it fatally undermines the strong sense of incommensurability which is the defining characteristic of pluralism as a distinct and radical doctrine. Alongside his view that values are commonly intelligible, Berlin retains a minimal ethical universalism, framed in terms of his concept of ‘negative liberty’, or freedom from unwarranted interference. Some have argued that this inviolable ‘core’ of human freedom constitutes a form of liberal universalism. Whilst I concede that Berlin’s objective pluralism does exhibit a decidedly Western character, I argue that his ‘core’ is in fact a rational and pragmatic assertion of the minimal conditions for any meaningful and sustainable human life, whatever its diverse forms, rather than an endorsement of any universalist claims of liberalism, even minimal ones. I further argue that the common intelligibility of values on which Berlin’s refutation of relativism can be thought convincingly to rest is possible only because there is an essence and continuity in human ideas of a kind which is denied by Quentin Skinner and the Cambridge School, and which enable the historical understanding we clearly can achieve.

It has become the norm for organisations in many industrial sectors to constantly operate in dynamic, uncertain and challenging business environments. Technology, regulations, global economy, changing political actions and international conditions are all changing rapidly, creating dynamic business conditions for organisations to understand, react to and thus survive. The Oil and Gas (O&G) sector which is the backbone of the economic growth for many countries in the Middle East region is not an exception to the real world of business filled with uncertainties. The construction of meaning or sensemaking is a prerequisite management skill for complex problem solving and decision-making for survival in today’s increasingly dynamic business environments. Current literature on sensemaking tends to focus on senior management’s role in the process, overlooking the critical role middle management teams play in the construction of meaning. Further, although sensemaking literature illustrates the influence of sensegiving and sensebreaking on sensemaking, there is limited empirical research in existing literature on how middle management teams apply sensegiving and sensebreaking to influence the process. Finally, this research fills a gap in sensemaking research in developing countries to decolonise Western-based research and ensure that local culture and ideologies are taken into account. In particular, it provides important data for the O&G sector in Bahrain, which is important for the Middle East region. Therefore, this research investigates how middle management teams use sensemaking to understand complex problems and how they apply sensegiving and sensebreaking to influence the sensemaking process in Bahrain’s O&G sector. The data was gathered using a qualitative approach using in-depth semi-structured interviews, middle management team meeting observations and operational documents review. The findings include seven themes and 26 sub-themes are visualised in a four-step sensemaking process framework. This framework also illustrates the sensemaking triggers and properties, as well as the influences and sources of information middle management teams adopt to construct meaning in dynamic O&G environments. Further, the four-step sensemaking process framework incorporates the different sensegiving and sensebreaking techniques embraced. This research extends the existing sensemaking literature by providing a descriptive empirical framework to better understand middle management team sensemaking, sensegiving and sensebreaking in dynamic O&G environments. This four-step sensemaking process framework gives middle management teams a way to organise information related to events in an objective manner, enabling them to develop effective reactions to a fast-changing environment. The framework also offers human resource practitioners a platform to assess and develop middle management sensemaking skills.

Objectives: Young onset dementia is associated with distinctive support needs but existing research on service provision has been largely small scale and qualitative. Our objective was to explore service use, cost and satisfaction across the UK. Methods: Information about socio‐demographic characteristics, service use and satisfaction were gathered from people with young onset dementia (YOD) and/or a family member/supporter via a national survey. Results: Two hundred and thirty‐three responses were analysed. Diagnosis was most commonly received through a Memory Clinic or Neurology. The type of service delivering diagnosis impacted on post‐diagnostic care. Those diagnosed in specialist YOD services were more likely to receive support within the first 6 weeks and receive ongoing care in the service where they were diagnosed. Ongoing care management arrangements varied but generally care was lacking. Around 42% reported no follow‐up during 6‐weeks after diagnosis; over a third reported seeing no health professional within the previous 3 months; just over a third had a key worker and just under a third had a care plan. Satisfaction and quality of care were highest in specialist services. Almost 60% of family members spent over 5 h per day caring; median costs of health and social care, 3 months, 2018, were £394 (interquartile range £389 to 640). Conclusions: Variation across diagnostic and post‐diagnostic care pathways for YOD leads to disparate experiences, with specialist young onset services being associated with better continuity, quality and satisfaction. More specialist services are needed so all with YOD can access age‐appropriate care.

Underwater communication applications extensively use localization services for object identification. Because of their significant impact on ocean exploration and monitoring, underwater wireless sensor networks (UWSN) are becoming increasingly popular, and acoustic communications have largely overtaken radio frequency (RF) broadcasts as the dominant means of communication. The two localization methods that are most frequently employed are those that estimate the angle of arrival (AOA) and the time difference of arrival (TDoA). The military and civilian sectors rely heavily on UWSN for object identification in the underwater environment. As a result, there is a need in UWSN for an accurate localization technique that accounts for dynamic nature of the underwater environment. Time and position data are the two key parameters to accurately define the position of an object. Moreover, due to climate change there is now a need to constrain energy consumption by UWSN to limit carbon emission to meet net-zero target by 2050. To meet these challenges, we have developed an efficient localization algorithm for determining an object position based on the angle and distance of arrival of beacon signals. We have considered the factors like sensor nodes not being in time sync with each other and the fact that the speed of sound varies in water. Our simulation results show that the proposed approach can achieve great localization accuracy while accounting for temporal synchronization inaccuracies. When compared to existing localization approaches, the mean estimation error (MEE) and energy consumption figures, the proposed approach outperforms them. The MEEs is shown to vary between 84.2154m and 93.8275m for four trials, 61.2256m and 92.7956m for eight trials, and 42.6584m and 119.5228m for twelve trials. Comparatively, the distance-based measurements show higher accuracy than the angle-based measurements.

Set in the context of efforts to utilise chemicals as weapons of war, that have their origins in collaborative efforts between the UK and the US during World War I, this chapter examines the origins, the evolution, and the hostile misuse of chemical anti-crop agents and defoliants. Out of efforts between the two countries that endured throughout World War II, military interest in chemical anti-crop agents and defoliants emerged in-part as a consequence of a close association between civilian chemistry and military chemistry. It is shown by way of insights provided from official sources from the United Kingdom (UK) National Archive that UK use of such agents in Malaya resulted in the emergence of new techniques concerning the large-scale use of chemical anti-plant agents, as well as methods for their widespread dissemination. It is argued here that the above can be seen as a prelude to subsequent use in Vietnam, the latter having implications of relevance to human health and for the environment. It is shown that the role of science policy experts in bringing influence to bear on policy-makers during the latter part of the Vietnam War was significant in bringing about change in policy and an end to use in Vietnam. Also of significance is the issue of chemical weapons in the context of efforts to codify the norm of non-use under the Geneva Protocol, under the Chemical Weapons Convention (CWC), and under a range of related prohibition regimes. This chapter considers the implications of the scientific and technological developments in phytobiology of relevance, in particular, to auxins (work on endogenous growth regulators—auxins—would lead to the discovery of “the first systemic or hormone herbicides”). The findings are drawn together in a concluding section at the end of this chapter.

The devastating effects of the COVID-19 pandemic have acutely shown the need for maintaining robust international and national systems for biological security and ensuring that life sciences are used only for peaceful purposes. Life science stakeholders can play an important role in safeguarding scientific and technological advances in biology and related fields against accidental or deliberate misuse, not least because they are on the frontlines of driving innovation. In this paper, we argue that enhancing awareness and understanding of the risk of deliberate disease is essential for effective biological security. We first discuss the issue of ‘dual use’ in science and technology as it relates to disarmament and non-proliferation of weapons of mass destruction. Second, we review how scientist engagement with dual-use risks has been addressed in the context of the Biological and Toxin Weapons Convention (BTWC). Third, we report on the development of an innovative awareness-raising tool, a cartoon series, that can be used for engaging life science stakeholders with BTWC issues. Finally, we outline a set of practical considerations for promoting sustainable life science engagement with the BTWC.

The COVID-19 virus pandemic has again demonstrated the devastating impact that a microbial pathogen can have on our health, society and economic systems. It necessitates a fundamental rethink of how the security of our societies can be better sustained. This rethinking will require many aspects of our security systems to be re-examined, but we concentrate here on the consequences of the rapid advances being made in the life and associated sciences. In this chapter, we will describe and analyse one of the most likely means by which the BTWC could be strengthened at the 9th Review Conference, namely: agreement of an International Aspirational Code of Conduct supported by mandatory biological security education for life and associated scientists. We conclude that a vigorous effort by civil society will be needed to assist the achievement of an agreement on this issue at the 9th Review Conference.