Now showing items 1-20 of 8226

    • Bioinformatics analysis of epigenetic variants associated with melanoma

      Poterlowicz, Krzysztof; Murat, Katarzyna (University of BradfordDepartment of Chemistry and Biosciences, 2018)
      The field of cancer genomics is currently being enhanced by the power of Epigenome-wide association studies (EWAS). Over the last couple of years comprehensive sequence data sets have been generated, allowing analysis of genome-wide activity in cohorts of different individuals to be increasingly available. Finding associations between epigenetic variation and phenotype is one of the biggest challenges in biomedical research. Laboratories lacking dedicated resources and programming experience require bioinformatics expertise which can be prohibitively costly and time-consuming. To address this, we have developed a collection of freely available Galaxy tools (Poterlowicz, 2018a), combining analytical methods into a range of convenient analysis pipelines with graphical user-friendly interface.The tool suite includes methods for data preprocessing, quality assessment and differentially methylated region and position discovery. The aim of this project was to make EWAS analysis flexible and accessible to everyone and compatible with routine clinical and biological use. This is exemplified by my work undertaken by integrating DNA methylation profiles of melanoma patients (at baseline and mitogen-activated protein kinase inhibitor MAPKi treatment) to identify novel epigenetic switches responsible for tumour resistance to therapy (Hugo et al., 2015). Configuration files are publicly published on our GitHub repository (Poterlowicz, 2018b) with scripts and dependency settings also available to download and install via Galaxy test toolshed (Poterlowicz, 2018a). Results and experiences using this framework demonstrate the potential for Galaxy to be a bioinformatics solution for multi-omics cancer biomarker discovery tool.
    • Propagation channel models for 5G mobile networks. Simulation and measurements of 5G propagation channel models for indoor and outdoor environments covering both LOS and NLOS Scenarios

      Abd-Alhameed, Raed A.; Manan, Waqas (University of BradfordFaculty of Engineering and Informatics, 2018)
      At present, the current 4G systems provide a universal platform for broadband mobile services; however, mobile traffic is still growing at an unprecedented rate and the need for more sophisticated broadband services is pushing the limits on current standards to provide even tighter integration between wireless technologies and higher speeds. This has led to the need for a new generation of mobile communications: the so-called 5G. Although 5G systems are not expected to penetrate the market until 2020, the evolution towards 5G is widely accepted to be the logical convergence of internet services with existing mobile networking standards leading to the commonly used term “mobile internet” over heterogeneous networks, with several Gbits/s data rate and very high connectivity speeds. Therefore, to support highly increasing traffic capacity and high data rates, the next generation mobile network (5G) should extend the range of frequency spectrum for mobile communication that is yet to be identified by the ITU-R. The mm-wave spectrum is the key enabling feature of the next-generation cellular system, for which the propagation channel models need to be predicted to enhance the design guidance and the practicality of the whole design transceiver system. The present work addresses the main concepts of the propagation channel behaviour using ray tracing software package for simulation and then results were tested and compared against practical analysis in a real-time environment. The characteristics of Indoor-Indoor (LOS and NLOS), and indoor-outdoor (NLOS) propagations channels are intensively investigated at four different frequencies; 5.8 GHz, 26GHz, 28GHz and 60GHz for vertical polarized directional, omnidirectional and isotropic antennas patterns. The computed data achieved from the 3-D Shooting and Bouncing Ray (SBR) Wireless Insite based on the effect of frequency dependent electrical properties of building materials. Ray tracing technique has been utilized to predict multipath propagation characteristics in mm-wave bands at different propagation environments. Finally, the received signal power and delay spread were computed for outdoor-outdoor complex propagation channel model at 26 GHz, 28 GHz and 60GHz frequencies and results were compared to the theoretical models.
    • Impact of state fragility on capital flows and economic growth in Nigeria

      Jalilian, Hossein; Potts, David J.; Laniran, Temitope J. (University of BradfordFaculty of Social Sciences, 2018)
      This thesis aims to investigate the impact of state fragility on capital inflows and economic growth in Nigeria over the period 1980-2015. In line with existing studies, it adopts an augmented neoclassical growth model where capital is divided into domestic and foreign capital inflows (FDI, ODA and Remittances). Using an autoregressive distributed lag (ARDL) bounds testing approach to co-integration, significant long-run relationship was confirmed between state fragility, capital flows and economic growth. The results reveal domestic capital to be very significant and contribute positively to economic growth. Similarly it was observed that remittances remain a very crucial form of capital flow to Nigeria and that the presence of state fragility makes it more significant. For ODA a positive contribution to economic growth was observed, however, the presence of state fragility renders it insignificant. In the case of FDI, the study found a negative relationship between FDI and economic growth albeit insignificant. However, the presence of state fragility makes it significant but still negative. A negative relationship was also observed between state fragility and economic growth. These findings, implies that while the issue of state fragility needs to be addressed and concerted efforts put into building state resilience, not just for the direct impact of state fragility on the economy, but also its impact on the economy through other channels such as capital flows.
    • Antenna design using optimization techniques over various computaional electromagnetics. Antenna design structures using genetic algorithm, Particle Swarm and Firefly algorithms optimization methods applied on several electromagnetics numerical solutions and applications including antenna measurements and comparisons

      Abd-Alhameed, Raed A.; Abdussalam, Fathi M.A. (University of BradfordFaculty of Engineering and Informatics, 2018)
      Dealing with the electromagnetic issue might bring a sort of discontinuous and nondifferentiable regions. Thus, it is of great interest to implement an appropriate optimisation approach, which can preserve the computational resources and come up with a global optimum. While not being trapped in local optima, as well as the feasibility to overcome some other matters such as nonlinear and phenomena of discontinuous with a large number of variables. Problems such as lengthy computation time, constraints put forward for antenna requirements and demand for large computer memory, are very common in the analysis due to the increased interests in tackling high-scale, more complex and higher-dimensional problems. On the other side, demands for even more accurate results always expand constantly. In the context of this statement, it is very important to find out how the recently developed optimization roles can contribute to the solution of the aforementioned problems. Thereafter, the key goals of this work are to model, study and design low profile antennas for wireless and mobile communications applications using optimization process over a computational electromagnetics numerical solution. The numerical solution method could be performed over one or hybrid methods subjective to the design antenna requirements and its environment. Firstly, the thesis presents the design and modelling concept of small uni-planer Ultra- Wideband antenna. The fitness functions and the geometrical antenna elements required for such design are considered. Two antennas are designed, implemented and measured. The computed and measured outcomes are found in reasonable agreement. Secondly, the work is also addressed on how the resonance modes of microstrip patches could be performed using the method of Moments. Results have been shown on how the modes could be adjusted using MoM. Finally, the design implications of balanced structure for mobile handsets covering LTE standards 698-748 MHz and 2500-2690 MHz are explored through using firefly algorithm method. The optimised balanced antenna exhibits reasonable matching performance including near-omnidirectional radiations over the dual desirable operating bands with reduced EMF, which leads to a great immunity improvement towards the hand-held.
    • The Impact of Visual Representations of Leadership in Tribal Dominated Societies: A critical qualitative study of aesthetic leadership in the United Arab Emirates

      Kelly, Simon; Harding, Nancy H.; Bitar, Amer (University of BradfordSchool of Management, 2017)
      This thesis explores the role and impact of leadership as a socially constructed and aesthetic phenomenon in tribal-dominated Bedouin Arabia. The concept of leadership is investigated in terms of its discursive and aesthetic dimensions across different geographical, historical, and intellectual settings by adopting and applying a Foucauldian perspective of interconnected concepts of power/knowledge, discourse, subjectivity, body symbolism and the power of gaze. The thesis draws on three related types of data: First, images to understand the leaders’ perspective. Second, interviews with artists to gain insights into the visual message and the creative process. Third, through semi-structured interviews with the audience to garner an understanding of how it perceives the message leaders send. This thesis contributes theoretically to ongoing research into the visual representation of leadership and to critical debates concerning Foucauldian perspectives on discourse, power, discipline and the body. This thesis concludes by recommending practical implications for rethinking leadership as something both aesthetic and mythical to consider the role of followership in the consumption of leadership-themed visual artworks and communication, and the growing global role and influence of social media in shaping leader-follower relations.
    • A case for peace photojournalism in Northern Ireland: A media content analysis.

      Not named; Shebib, Lisa A. (University of BradfordDepartment of Peace Studies, 2017)
      Contemporary studies of Peace Journalism have yet to examine how photographs, as visual content captured by print media, fit within the model of Peace Journalism. In this research, a content analysis of press images was conducted using predefined methodology on newspaper coverage of the annual July 12th Drumcree Parades (Marching) in Portadown, Northern Ireland, during the pre-, intra-, and post-peace process that occurred between 1996 and 2000. In most newspapers, the proportions of both violent/aggressive and nonviolent/non-peaceful content were higher in the relatively peaceful period of 2000, as compared to their proportions in at least one of the other ‘violent’ years of 1996 and 1998. No overall trend in content was observed in relation to the level of violence across 1996 to 2000. During this period, media practice in Portadown, Northern Ireland did not support the publication of newspaper commensurate with actual level of violence in the Northern Ireland or the depictions of peace building and the peaceful resolution of conflict. The implications of these findings for the development of ‘Peace Photojournalism’ are explored.
    • Biomechanical adaptations involved in ramp descent: Impact of microprocessor-controlled ankle-foot prothesis. Kinetic and kinematic responses to using microprocessor-controlled ankle-foot prosthesis in unilateral trans-tibial amputees during ramp descent

      Buckley, John G.; Beggs, Clive B.; Struckovs, Vasilijs (University of BradfordDivision of Medical Engineering, School of Engineering and Informatics, 2017)
      Ramp descent is a demanding task for trans-tibial amputees, due to the difficulty in controlling body weight progression over the prosthetic foot. A deeper understanding of the impact of foot function on ramp descent biomechanics is required to make recommendations for rehabilitation programs and prosthetic developments for lower-limb amputees. The thesis aim was to determine the biomechanical adaptations made by active unilateral trans-tibial amputees (TT) using a microprocessor-controlled ankle-foot prosthesis in active (MC-AF) compared to non-active mode (nonMC-AF) or elastically articulated ankle-foot device. A secondary aim was to determine the biomechanical adaptation made by able-bodied individuals when ankle motion was restricted using a custom made ankle-foot-orthosis and provide further insight into the importance of ankle dynamics when walking on ramps. Kinetic and kinematic data were recorded from nine TT’s and twenty able-bodied individuals. Able-bodied participants, ankle restriction, led to an increase in involved limb loading response knee flexion that is accompanied by the increased knee power generation during the single-limb-support phase that correlates to TTs results. TT’s use of an MC-AF reduced the ‘plantar-flexion’ resistance following foot contact allowing foot-flat to be attained more quickly. Followed by the increased ‘dorsi-flexion’ resistance which reduced the shank/pylon rotation velocity over the support foot, leading to an increase in negative work done by the prosthesis. These findings highlight the importance of having controlled ankle motion in ramp descent. Use of an MC-AF can provide TTs controlled motion for descending ramps and hence provide biomechanical benefits over using more conventional types of ankle-foot devices.
    • Examining the gap between employees’ expectations and their experience of HR practices in luxury five-star hotels in Thailand. A cross-sector comparison of local hotels, national and international chains hotels

      Glaister, Alison J.; Suengkamolpisut, Wallapa (University of BradfordFaculty of Management & Law, 2017)
      Tourism and hospitality play a crucial role in the growth of the Thai economy and hoteliers need to consider how to retain their talented employees. The major output of tourism and hospitality is service and this is most critically driven by the human capital of the organisation and supported by human resource practices. This study examined workforce expectations and experiences of work relationships, job security, WLB, pay and remuneration, PM systems, career promotion, training and development and challenging job roles in luxury five-star hotels in Thailand. It employs a multi-method research design using a pragmatic lens, mixed methods and sequential explanatory design through a survey of 578 respondents, followed by 62 semi-structured interviews, the study shows that national chain hotels are more willing and better able to adapt their HR practices initiatives to local conditions when compared to local and international chain hotels. Thai hotel employees emphasise harmonious social relations and a physical closeness to be taken care of by their supervisors and management team like family members. They are increasingly aware of the need for bundles of HR practices and managers therefore need to understand their workforce and the need to incorporate more flexibility in their working practices as part of a brandconsistent system. Finally, managers need to consider the relational psychological contract of the workforce and understand workforce commitment and how this relates to the broader strategy of the organisation.
    • Bog bodies in context: developing a best practice approach

      Chapman, H.; Van Beek, R.; Gearey, B.; Jennings, Benjamin R.; Smith, D.; Nielsen, N.H.; Elabdin, Z.Z. (2019)
      Bog bodies are among the best-known archaeological finds worldwide. Much of the work on these often extremely well-preserved human remains has focused on forensics, whereas the environmental setting of the finds has been largely overlooked. This applies to both the ‘physical’ and ‘cultural’ landscape and constitutes a significant problem since the vast spatial and temporal scales over which the practice appeared demonstrate that contextual assessments are of the utmost importance for our explanatory frameworks. In this article we develop best practice guidelines for the contextual analysis of bog bodies after having assessed the current state of research and presented the results of three recent case studies including the well-known finds of Lindow Man in the United Kingdom, Bjældskovdal (Tollund Man and Elling Woman) in Denmark, and Yde Girl in the Netherlands. Three spatial and chronological scales are distinguished and linked to specific research questions and methods. This provides a basis for further discussion and a starting point for developing approaches to bog body finds and future discoveries, while facilitating and optimising the re-analysis of previous studies, making it possible to compare deposition sites across time and space.
    • Identifying reputation collectors in community question answering (CQA) sites: Exploring the dark side of social media

      Roy, P.K.; Singh, J.P.; Baabdullah, A.M.; Kizgin, Hatice; Rana, Nripendra P. (2018-10)
      This research aims to identify users who are posting as well as encouraging others to post low-quality and duplicate contents on community question answering sites. The good guys called Caretakers and the bad guys called Reputation Collectors are characterised by their behaviour, answering pattern and reputation points. The proposed system is developed and analysed over publicly available Stack Exchange data dump. A graph based methodology is employed to derive the characteristic of Reputation Collectors and Caretakers. Results reveal that Reputation Collectors are primary sources of low-quality answers as well as answers to duplicate questions posted on the site. The Caretakers answer limited questions of challenging nature and fetches maximum reputation against those questions whereas Reputation Collectors answers have so many low-quality and duplicate questions to gain the reputation point. We have developed algorithms to identify the Caretakers and Reputation Collectors of the site. Our analysis finds that 1.05% of Reputation Collectors post 18.88% of low quality answers. This study extends previous research by identifying the Reputation Collectors and 2 how they collect their reputation points.
    • Disaster management in Bangladesh: developing an effective emergency supply chain network

      Shareef, M.A.; Dwivedi, Y.K.; Mahmud, R.; Wright, A.; Rahman, M.M.; Kizgin, Hatice; Rana, Nripendra P. (2018-10)
      This study has addressed and identified the problems in managing the existing emergency supply chain of Bangladesh in all phases of operation in terms of the primary drivers of the supply chain. It has also attempted to conceptualize and suggest an effective emergency supply chain. In this context, a thorough field investigation in several districts was conducted among the employees of the organizations sharing common information with similar protocols and implications (interoperable). Information was collected from the employees of all the participating organizations involved in disaster management through a semi-structured questionnaire based survey. The respondents addressed and illustrated several interconnected reasons which are inhibiting proper forecasting, procurement, storage, identification of affected people, and distribution. The respondents pointed out that the mismatching of objectives in the different organizations resulted in non-interoperability among the participating organizations. These issues are related to the malfunctioning of management with multidimensional organizational conflicts. Reflecting those issues, an emergency supply chain for disaster management is proposed in this study
    • Consumption of products from heritage and host cultures: The role of acculturation attitudes and behaviors

      Kizgin, Hatice; Jamal, A.; Richard, M-O. (2018-01)
      Prior research ignores the specific role of acculturation attitudes in predicting acculturation behaviors and consumption choices across public and private life domains. The study uses self-administered questionnaires to collect data from 530 Turkish-Dutch respondents. The findings underscore the overall significance of investigating domain-specific (public vs. private) acculturation attitudes and subsequent acculturation behaviors. Enculturation (acculturation) behaviors function as a mediating variable in the relationship between acculturation attitudes and consumption of food and entertainment products from the heritage (host) culture. The study is one of the first to investigate the simultaneous effects of acculturation attitudes and acculturation behaviors on the choice to consumer foods and entertainment products from both heritage and host cultures. The article provides managerial implications and future research directions.
    • Consumer use of mobile banking (M-Banking) in Saudi Arabia: Towards an integrated model

      Baabdullah, A.M.; Alalwan, A.A.; Rana, N.P.; Kizgin, Hatice; Patil, P. (2019-02)
      Mobile banking is one of the most promising technologies that has emerged in recent years and could prove to have considerable value to both banks and customers. Thus, this study recognises the need to test the main factors that could predict the use of mobile banking as well as how using such a system could contribute to both customer satisfaction and customer loyalty. The conceptual model of this study combines two models (i.e. UTAUT2 and the D&M IS Success Model). A questionnaire survey was conducted to collect the required data from convenience sampling of Saudi bank customers. The main factors – performance expectancy, price value, facilitating conditions, hedonic motivation, habit, system quality and service quality – were found to have a significant impact on actual use behaviour. This study was cross-sectional, therefore future studies should implement longitudinal studies in order to re-collect the findings. Further, this study adopted convenience sampling of Saudi M-Banking users. This may adversely impact the issue of generalisability to the whole population. The gap in the M-Banking literature in Saudi Arabia would be bridged by proposing a comprehensive conceptual model that scrupulously clarifies the use of M-Banking from the perspective of Saudi users. Furthermore, this study would consider the adoption of numeric data in order to inferentially analyse them using SEM. This in turn would assist in generalising the findings to the whole Saudi population.
    • Impact of acculturation, online participation and involvement on voting intentions

      Jamal, A.; Kizgin, Hatice; Rana, N.P.; Laroche, M.; Dwivedi, Y.K. (2019-07)
      This study examines the extent to which acculturation and enculturation orientations affect online political participation, political involvement and voting intentions among a sample of Turkish-Dutch immigrants. The study uses data from Turkish-Dutch participants. Structural Equations Modelling (SEM) is employed for assessing the relationships in the conceptualized model. The findings show that enculturation and acculturation influence online participation and involvement, which in turn, are related to voting intentions. The study further examines the mediating role of political involvement and online political participation. Political involvement mediates the relationships between enculturation and acculturation and voting intentions. The results further indicate the effect of online participation on voting intentions is mediated by political involvement. The study findings provide insights into offline and online cultural and civic engagement tendencies among an important immigrant segment that policy makers should consider in the future.
    • Artificial Intelligence (AI): Multidisciplinary Perspectives on Emerging Challenges, Opportunities, and Agenda for Research, Practice and Policy

      Dwivedi, Y.K.; Hughes, L.; Ismagilova, Elvira; Aarts, G.; Coombs, C.; Crick, T.; Duan, Y.; Dwivedi, R.; Edwards, J.; Eirug, A.; et al. (Elsevier, 2019)
      As far back as the industrial revolution, significant development in technical innovation has succeeded in transforming numerous manual tasks and processes that had been in existence for decades where humans had reached the limits of physical capacity. Artificial Intelligence (AI) offers this same transformative potential for the augmentation and potential replacement of human tasks and activities within a wide range of industrial, intellectual and social applications. The pace of change for this new AI technological age is staggering, with new breakthroughs in algorithmic machine learning and autonomous decision-making, engendering new opportunities for continued innovation. The impact of AI could be significant, with industries ranging from: finance, healthcare, manufacturing, retail, supply chain, logistics and utilities, all potentially disrupted by the onset of AI technologies. The study brings together the collective insight from a number of leading expert contributors to highlight the significant opportunities, realistic assessment of impact, challenges and potential research agenda posed by the rapid emergence of AI within a number of domains: business and management, government, public sector, and science and technology. This research offers significant and timely insight to AI technology and its impact on the future of industry and society in general, whilst recognising the societal and industrial influence on pace and direction of AI development.
    • Recent advances in the analysis of polysialic acid from complex biological systems

      Guo, Xiaoxiao; Elkashelf, Sara M.; Loadman, Paul M.; Patterson, Laurence H.; Falconer, Robert A. (2019-11-15)
      Polysialic acid (polySia) is a unique, well-characterised carbohydrate polymer highly-expressed on the cell surface of neurons in the early stages of mammalian brain development. Post-embryogenesis, it is also re-expressed in a number of tumours of neuroendocrine origin. It plays important roles in modulating cell-cell, and cell-matrix adhesion and migration, tumour invasion and metastasis. Techniques for structural and quantitative characterisation of polySia from tumours and cancer cells are thus essential in exploring the relationship between polySia expression levels and structural and functional changes associated with cancer progression and metastasis. A variety of techniques have been developed to structurally and quantitatively analyse polySia in clinical tissues and other biological samples. In this review, analytical approaches used for the determination of polySia in biological matrices in the past 20 years are discussed, with a particular focus on chemical approaches, and quantitative analysis.
    • Controlling the material removal and roughness of Inconel 718 in laser machining

      Ahmed, N.; Rafaqat, M.; Pervaiz, S.; Umer, U.; Alkhalefa, H.; Baloch, Muhammad A.S.; Mian, S.H. (2019-05-16)
      Nickel alloys including Inconel 718 are considered as challenging materials for machining. Laser beam machining could be a promising choice to deal with such materials for simple to complex machining features. The machining accuracy is mainly dependent on the rate of material removal per laser scan. Because of the involvement of many laser parameters and complexity of the machining mechanism it is not always simple to achieve machining with desired accuracy. Actual machining depth extremely varies from very low to aggressively high values with reference to the designed depth. Thus, a research is needed to be carried out to control the process parameters to get actual material removal rate (MRRact) equals to the theoretical material removal rate (MRRth) with minimum surface roughness (SR) of the machined surfaces. In this study, five important laser parameters have been used to investigate their effects on MRR and SR. Statistical analysis are performed to identify the significant parameters with their strength of effects. Mathematical models have been developed and validated to predict the machining responses. Optimal set of laser parameters have also been proposed and confirmed to achieve the actual MRR close to the designed MRR (MRR% = 100.1%) with minimum surface roughness (Ra = 2.67 µm).
    • Tunable supramolecular gel properties by varying thermal history

      Debnath, S.; Roy, S.; Abul-Haija, Y.M.; Frederix, P.W.J.M.; Ramalhete, S.M.; Hirst, A.R.; Javid, Nadeem; Hunt, N.T.; Kelly, S.M.; Angulo, J.; et al. (2019-06-12)
      The possibility of using differential pre‐heating prior to supramolecular gelation to control the balance between hydrogen‐bonding and aromatic stacking interactions in supramolecular gels and obtain consequent systematic regulation of structure and properties is demonstrated. Using a model aromatic peptide amphiphile, Fmoc‐tyrosyl‐leucine (Fmoc‐YL) and a combination of fluorescence, infrared, circular dichroism and NMR spectroscopy, it is shown that the balance of these interactions can be adjusted by temporary exposure to elevated temperatures in the range 313–365 K, followed by supramolecular locking in the gel state by cooling to room temperature. Distinct regimes can be identified regarding the balance between H‐bonding and aromatic stacking interactions, with a transition point at 333 K. Consequently, gels can be obtained with customizable properties, including supramolecular chirality and gel stiffness. The differential supramolecular structures also result in changes in proteolytic stability, highlighting the possibility of obtaining a range of supramolecular architectures from a single molecular structure by simply controlling the pre‐assembly temperature.
    • Investigation of molecular and mesoscale clusters in undersaturated glycine aqueous solutions

      Zimbitas, G.; Jawor-Baczynska, A.; Vesga, M.J.; Javid, Nadeem; Moore, B.D.; Parkinson, J.; Sefcik, J. (2019-10)
      In this work DLS, NTA, SAXS and NMR were used to investigate populations, size distributions and structure of clusters in undersaturated aqueous solutions of glycine. Molecular and colloidal scale (mesoscale) clusters with radii around 0.3-0.5 nm and 100–150 nm, respectively, were observed using complementary experimental techniques. Molecular clusters are consistent with hydrated glycine dimers present in equilibrium with glycine monomers in aqueous solutions. Mesoscale clusters previously observed in supersaturated glycine solutions appear to be indefinitely stable, in mutual equilibrium within mesostructured undersaturated solutions across all glycine concentrations investigated here, down to as low as 1 mg/g of water.
    • Psoriasis activation of cells important in cardiovascular disease

      Graham, Anne M.; Wittmann, Miriam; Bridgewood, Charlie (University of BradfordFaculty of Life Sciences, 2017)
      Psoriasis is an immune mediated inflammatory disease which affects 2-3% of the world’s population. Over the last decade, psoriasis has been acknowledged as an independent risk factor for atherosclerosis. The precise mechanism or mechanisms of the heightened risk is widely speculated. Endothelial cells and macrophages are central players in the immunopathological development of both diseases. Interleukin-36 cytokines (IL-36) have been heavily implicated in psoriasis immunopathology. Significant upregulation of epidermal IL-36 is a recognised characteristic of psoriatic skin inflammation. IL-36 induces inflammatory responses in dendritic cells, fibroblasts and epithelial cells. While vascular alterations are a hallmark of psoriatic lesions and dermal endothelial cells are well known to play a critical role in dermal inflammation, the effects of IL-36 on endothelial cells have not been defined. We report that endothelial cells including dermal microvascular cells express a functionally active IL-36 receptor. Adhesion molecules VCAM-1 and ICAM-1 are upregulated following IL-36γ stimulation, and this is reversed in the presence of the endogenous IL-36 receptor antagonist. IL-36γ-stimulated endothelial cells secrete the proinflammatory chemokines IL-8, CCL2 and CCL20. Chemotaxis assays showed increased migration of T-cells following IL-36γ stimulation of endothelial cells. Both resident and infiltrating inflammatory myeloid cells contribute to the immunopathology of psoriasis by promoting the IL-23/IL-17 axis. We show that IL-36γ induces the production of psoriasis-associated cytokines from macrophages (IL-23, TNFα) and that this response is enhanced in macrophages from psoriasis patients. This effect is specific for IL-36γ and could not be mimicked by other IL-1 family cytokines such as IL-1α. Furthermore, IL-36γ stimulated macrophages potently activated endothelial cells as illustrated by ICAM-1(CD54) upregulation, and led to increased adherence of monocytes, effects that were markedly more pronounced for psoriatic macrophages. Interestingly, regardless of stimulus, monocytes isolated from psoriasis patients showed increased adherence to both the stimulated and unstimulated endothelium when compared to monocytes from healthy individuals. Collectively, these findings add to the growing evidence for IL-36γ having roles in psoriatic responses, by enhancing endothelium directed leukocyte infiltration into the skin and strengthening the IL-23/IL-17 pathway. Our findings also point to a cellular response which could potentially support cardiovascular comorbidities in psoriasis.