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dc.contributor.authorSheldrake, Helen M.*
dc.contributor.authorPatterson, Laurence H.*
dc.date.accessioned2016-10-19T13:16:49Z
dc.date.available2016-10-19T13:16:49Z
dc.date.issued2014
dc.identifier.citationSheldrake HM and Patterson LH (2014) Strategies to inhibit tumour associated integrin receptors: rationale for dual and multi-antagonists. Journal of Medicinal Chemistry. 57(15): 6301-6315.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9984
dc.descriptionYesen_US
dc.description.abstractThe integrins are a family of 24 heterodimeric transmembrane cell surface receptors. Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies integrins as therapeutic targets in cancer and associated conditions; thrombosis, angiogenesis and osteoporosis. The most reported strategy for drug development is synthesis of an agent that is highly selective for a single integrin receptor. However, the ability of cancer cells to change their integrin repertoire in response to drug treatment renders this approach vulnerable to the development of resistance and paradoxical promotion of tumor growth. Here, we review progress towards development of antagonists targeting two or more members of the RGD-binding integrins, notably αvβ3, αvβ5, αvβ6, αvβ8, α5β1, and αIIbβ3, as anticancer therapeutics.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1021/jm5000547en_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Medicinal Chemistry, copyright © 2014 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/jm5000547en_US
dc.subjectIntegrins; RGD-binding integrins; Cancer; Development of antagonists; Anticancer therapeuticsen_US
dc.titleStrategies to inhibit tumour associated integrin receptors: rationale for dual and multi-antagonistsen_US
dc.status.refereedYesen_US
dc.date.application2014-02-25
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-27T02:00:01Z


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