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dc.contributor.authorDe Paoli, M.
dc.contributor.authorPerco, P.
dc.contributor.authorMühlberger, I.
dc.contributor.authorLukas, A.
dc.contributor.authorPandha, H.S.
dc.contributor.authorMorgan, Richard
dc.contributor.authorFeng, G.J.
dc.contributor.authorMarquette, C.
dc.date.accessioned2016-10-12T11:33:32Z
dc.date.available2016-10-12T11:33:32Z
dc.date.issued2015-07-31
dc.identifier.citationDe Paoli M, Perco P, Mühlberger I et al. (2015) Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic. Biomarkers. 20(5): 328-337.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9897
dc.descriptionYesen_US
dc.description.abstractContext: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of de novo and recurrent bladder cancer. Objective: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer. Materials and methods: Urinary biomarkers concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis. Results: A 5-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set. Discussion and conclusion: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.en_US
dc.description.sponsorshipThis work has been supported in part by the European Commission Program DIPROMON - HEALTH-F5-2012-306157-2: Development of an integrated protein- and cell-based device for non-invasive diagnostics in the urogenital tract.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.3109/1354750X.2015.1068867en_US
dc.rights© 2015 Taylor & Francis. This is an Author's Original Manuscript of an article published by Taylor & Francis in Biomarkers on 31 Jul 2015, available online at http://www.tandfonline.com/10.3109/1354750X.2015.1068867en_US
dc.subjectBiomarkers; Bladder cancer; Invasiveness; Recurrenceen_US
dc.titleDisease map-based biomarker selection and pre-validation for bladder cancer diagnosticen_US
dc.status.refereedYesen_US
dc.date.Accepted2015-06-10
dc.date.application2015-07-31
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2018-07-25T14:27:09Z


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