View/ Open
Morgan_Current_Molecular_Medicine.pdf (350.3Kb)
Download
Publication date
01/05/2016Rights
The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/openurl/content.php?genre=article&doi=10.2174/ 1566524016666160316145715Peer-Reviewed
YesOpen Access status
openAccess
Metadata
Show full item recordAbstract
Circulating tumour cells (CTCs) have significant diagnostic potential as they can reflect both the presence and recurrence of a wide range of cancers. However, this potential continues to be limited by the lack of robust and accessible isolation technologies. An alternative to isolation might be their direct detection amongst other peripheral blood cells, although this would require markers that allow them to be distinguished from an exceptionally high background signal. This review assesses the potential role of HOX genes, a family of homeodomain containing transcription factors with key roles in both embryonic development and oncogenesis, as unique and possibly disease specific markers of CTCs.Version
Accepted manuscriptCitation
Morgan R and El-Tanani M (2016) HOX genes as potential markers of circulating tumour cells. Current Molecular Medicine. 16(4): 322-327.Link to Version of Record
https://doi.org/10.2174/1566524016666160316145715Type
Articleae974a485f413a2113503eed53cd6c53
https://doi.org/10.2174/1566524016666160316145715