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dc.contributor.authorAbdullahi, Mohamed H.
dc.contributor.authorThompson, L.M.
dc.contributor.authorBearpark, M.J.
dc.contributor.authorVinader, Victoria
dc.contributor.authorAfarinkia, Kamyar
dc.date.accessioned2016-10-11T09:22:06Z
dc.date.available2016-10-11T09:22:06Z
dc.date.issued2016-10-06
dc.identifier.citationAbdullahi MH, Thompson LM, Bearpark MJ et al (2016) The role of substituents in retro Diels–Alder extrusion of CO2 from 2(H)-pyrone cycloadducts. Tetrahedron. 72(40): 6021-6024.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9888
dc.descriptionYesen_US
dc.description.abstractAn experimental and computational investigation is conducted into the role of substituents in retro Diels-Alder extrusion of CO2 from 2-oxa-bicyclo[2.2.2]oct-5-en-3-ones. We provide the first experimental evidence that loss of CO2 from the cycloadducts significantly depends on the nature and position of the substituents. For example, we show that whilst 5-carboethoxy-2-pyrone undergoes a more facile cycloaddition that 3-carboethoxy-2-pyrone, the cycloadduct from the latter pyrone undergoes a more facile loss of CO2 than the cycloadduct from the former pyrone.en_US
dc.description.sponsorshipEPSRC, Yorkshire Cancer Research, Yorkshire Enterprise Fellowshipsen_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1016/j.tet.2016.07.066en_US
dc.subjectExtrusion of CO2; Diels-Alder cycloaddition; 2(H)-pyrone; DFT; Synthesis; Role of substituentsen_US
dc.titleThe role of substituents in retro Diels-Alder extrusion of CO2 from 2(H)-pyrone cycloadductsen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-07-26
dc.date.application2016-07-27
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US


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