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dc.contributor.authorSmall, Neil A.*
dc.contributor.authorBittles, A.H.*
dc.contributor.authorPetherick, E.S.*
dc.contributor.authorWright, J.*
dc.date.accessioned2016-10-07T15:45:56Z
dc.date.available2016-10-07T15:45:56Z
dc.date.issued2016
dc.identifier.citationSmall NA, Bittles AH, Petherick ES and Wright J (2016) Endogamy, consanguinity and the health implications of changing marital choices. Journal of Biosocial Science. Article in Press.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9802
dc.descriptionYesen_US
dc.description.abstractThe biraderi (brotherhood) is a long-established, widely prevalent dimension of social stratification in Pakistani communities worldwide. Alongside consanguinity, it offers a route for cementing social solidarities and so has strong sociobiological significance. A detailed breakdown of biraderi affiliation among participants in an ongoing birth cohort study in the Northern English city of Bradford is presented. There is historical resilience of intra-biraderi marriage, but with a secular decline in prevalence across all biraderi and considerable reductions in some. While a majority of marriages in all biraderi are consanguineous the prevalence varies, ranging from over 80% to under 60%. In consanguineous unions, first cousin marriages account for more than 50% in five of the 15 biraderi and >40% in six others. Within-biraderi marriage and consanguinity enhance genetic stratification, thereby increasing rates of genomic homozygosity and the increased expression of recessive genetic disorders. The trends we report constitute putative signals of generational change in the marital choices in this community.en_US
dc.description.sponsorshipWellcome Trusten_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1017/S0021932016000419en_US
dc.rights(c) 2016 Cambridge University Press. Full-text reproduced in accordance with the publisher's self-archiving policy.en_US
dc.subjectGenetics; Health; Consanguinityen_US
dc.titleEndogamy, consanguinity and the health implications of changing marital choicesen_US
dc.status.refereedYesen_US
dc.date.Accepted2016-08
dc.date.application2016-08-30
dc.typeArticleen_US
dc.type.versionAccepted Manuscripten_US
refterms.dateFOA2017-09-01T00:00:00Z


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