Integrating phenotype-genotype data for prioritization of candidate symptom genes
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KeywordsSymptom gene prioritisation; Phenotype-genotype data integration; Complex network
Symptoms and signs (symptoms in brief) are the essential clinical manifestations for traditional Chinese medicine (TCM) diagnosis and treatments. To gain insights into the molecular mechanism of symptoms, this paper presents a network-based data mining method to integrate multiple phenotype-genotype data sources and predict the prioritizing gene rank list of symptoms. The result of this pilot study suggested some insights on the molecular mechanism of symptoms.