Show simple item record

dc.contributor.authorSoon, Chin Fhong*
dc.contributor.authorGenedy, Mohamed A.*
dc.contributor.authorYouseffi, Mansour*
dc.contributor.authorDenyer, Morgan C.T.*
dc.date.accessioned2016-10-07T14:39:15Z
dc.date.available2016-10-07T14:39:15Z
dc.date.issued2013
dc.identifier.citationSoon CF, Genedy M, Youseffi M and Denyer MC (2013) Cell traction force mapping in MG63 and HaCaTs. Advanced Materials Research. 832: 39-44.
dc.identifier.urihttp://hdl.handle.net/10454/9733
dc.descriptionNo
dc.description.abstractThe ability of a cell to adhere and transmit traction forces to a surface reveals the cytoskeleton integrity of a cell. Shear sensitive liquid crystals were discovered with new function in sensing cell traction force recently. This liquid crystal has been previously shown to be non-toxic, linear viscoelastic and sensitive to localized exerted forces. This paper reports the possibility of extending the application of the proposed liquid crystal based cell force sensor in sensing traction forces of osteoblast-like (MG-63) and human keratinocyte (HaCaT) cell lines exerted to the liquid crystal sensor. Incorporated with cell force measurement software, force distributions of both cell types were represented in force maps. For these lowly contractile cells, chondrocytes expressed regular forces (10 – 90 nN, N = 200) around the circular cell body whereas HaCaT projected forces (0 – 200 nN, N = 200) around the perimeter of poly-hedral shaped body. These forces are associated with the organisation of the focal adhesion expressions and stiffness of the LC substrate. From the results, liquid crystal based cell force sensor system is shown to be feasible in detecting forces of both MG63 and HaCaT.
dc.relation.isreferencedbyhttps://doi.org/10.4028/www.scientific.net/AMR.832.39
dc.subjectCell force sensor; Cell traction force; Keratinocytes; Liquid crystal; Osteosarcoma
dc.titleCell Traction Force Mapping in MG63 and HaCaTs
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text available in the repository


This item appears in the following Collection(s)

Show simple item record