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dc.contributor.authorKulkarni, Chaitrali S.*
dc.contributor.authorKelly, Adrian L.*
dc.contributor.authorKendrick, John*
dc.contributor.authorGough, Timothy D.*
dc.contributor.authorParadkar, Anant R*
dc.date.accessioned2016-10-07T14:34:30Z
dc.date.available2016-10-07T14:34:30Z
dc.date.issued2013
dc.identifier.citationKulkarni C, Kelly AL, Kendrick J et al (2013) Mechanism for Polymorphic Transformation of Artemisinin during High Temperature Extrusion. Crystal Growth and Design. 13(12): 5157-5161.
dc.identifier.urihttp://hdl.handle.net/10454/9678
dc.descriptionNo
dc.description.abstractA novel, green, and continuous method for solid-state polymorphic transformation of artemisinin by high temperature extrusion has recently been demonstrated. This communication describes attempts to understand the mechanisms causing phase transformation during the extrusion process. Polymorphic transformation was investigated using hot stage microscopy and a model shear cell. At high temperature, phase transformation from orthorhombic to the triclinic crystals was observed through a vapor phase. Under mechanical stress, the crystalline structure was disrupted continuously, exposing new surfaces and accelerating the transformation process.
dc.language.isoen
dc.subjectHot-melt extrusion
dc.subjectPphase
dc.titleMechanism for Polymorphic Transformation of Artemisinin during High Temperature Extrusion
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1021/cg400891b
dc.openaccess.statusclosedAccess


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