BRADFORD SCHOLARS

    • Sign in
    View Item 
    •   Bradford Scholars
    • Engineering and Informatics
    • Engineering and Informatics Publications
    • View Item
    •   Bradford Scholars
    • Engineering and Informatics
    • Engineering and Informatics Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of Bradford ScholarsCommunitiesAuthorsTitlesSubjectsPublication DateThis CollectionAuthorsTitlesSubjectsPublication Date

    My Account

    Sign in

    HELP

    Bradford Scholars FAQsCopyright Fact SheetPolicies Fact SheetDeposit Terms and ConditionsDigital Preservation Policy

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Changes of cine cerebrospinal fluid dynamics in patients with multiple sclerosis treated with percutaneous transluminal angioplasty: a case-control study

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Publication date
    2013
    Author
    Zivadinov, R.
    Magnano, C.R.
    Galeotti, R.
    Schirda, C.V.
    Menegatti, E.
    Weinstock-Guttman, B.
    Marr, K.
    Bartolomei, I.
    Hagemeier, J.
    Malagoni, A.M.
    Hojnacki, D.
    Kennedy, C.
    Carl, E.
    Beggs, Clive B.
    Salvi, F.
    Zamboni, P.
    Show allShow less
    Keyword
    Adolescent
    ; Adult
    ; Aged
    ; Angioplasty
    ; Case-control studies
    ; Cerebral veins
    ; Cerebrospinal fluid
    ; Chronic disease
    ; Female
    ; Humans
    ; Magnetic Resonance Angiography
    ; Male
    ; Middle aged
    ; Multiple Sclerosis
    ; Treatment outcome
    ; Venous insufficiency
    ; Video recording
    ; Young adult
    Show allShow less
    Peer-Reviewed
    Yes
    
    Metadata
    Show full item record
    Abstract
    The purpose of this article is to investigate characteristics of cine phase contrast-calculated cerebrospinal fluid (CSF) flow and velocity measures in patients with relapsing-remitting (RR) multiple sclerosis (MS) receiving standard medical treatment who had been diagnosed with chronic cerebrospinal venous insufficiency (CCSVI) and underwent percutaneous transluminal angioplasty (PTA). This case-controlled, magnetic resonance (MR) imaging-blinded study included 15 patients with RR MS who presented with significant stenoses (>/=50% lumen reduction on catheter venography) in the azygous or internal jugular veins. Eight patients underwent PTA in addition to medical therapy immediately following baseline assessments (case group) and seven had delayed PTA after 6 months of medical therapy alone (control group). CSF flow and velocity measures were quantified over 32 phases of the cardiac cycle by a semiautomated method. Outcomes were compared between groups at baseline and at 6 and 12 months of the study by mixed-effect model analysis. At baseline, no significant differences in CSF flow or velocity measures were detected between groups. At month 6, significant improvement in flow (P<.001) and velocity (P = .013) outcomes were detected in the immediate versus the delayed group, and persisted to month 12 (P = .001 and P = .021, respectively). Within-group flow comparisons from baseline to follow-up showed a significant increase in the immediate group (P = .033) but a decrease in the delayed group (P = .024). Altered CSF flow and velocity measures were associated with worsening of clinical and MR outcomes in the delayed group. PTA in patients with MS with CCSVI increased CSF flow and decreased CSF velocity, which are indicative of improved venous parenchyma drainage.
    URI
    http://hdl.handle.net/10454/9561
    Version
    No full-text available in the repository
    Citation
    Zivandinov R, Magnano CR, Galeotti R (2013) Changes of cene cerebrospinal fluid dynamics in patients with multiple sclerosis treated with percutaneous transluminal angioplasty: a case-control study. Journal of Vascular and Interventional Radiology. 24(6): 829-838.
    Link to publisher’s version
    http://dx.doi.org/10.1016/j.jvir.2013.01.490
    Type
    Article
    Collections
    Engineering and Digital Technology Publications

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.