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dc.contributor.authorMathew, G.*
dc.contributor.authorMitchell, Andrew*
dc.contributor.authorDown, J.M.*
dc.contributor.authorJacobs, L.A.*
dc.contributor.authorHamdy, F.C.*
dc.contributor.authorEaton, C.*
dc.contributor.authorRosario, D.J.*
dc.contributor.authorCross, S.S.*
dc.contributor.authorWinder, S.J.*
dc.date.accessioned2016-10-07T13:06:29Z
dc.date.available2016-10-07T13:06:29Z
dc.date.issued2013
dc.identifier.citationMathew G, Mitchell A, Down JM et al (2013) Nuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer. Scientific Reports, 3. Article Number 2792.
dc.identifier.urihttp://hdl.handle.net/10454/9555
dc.description.abstractDystroglycan is frequently lost in adenocarcinoma, but the mechanisms and consequences are poorly understood. We report an analysis of beta-dystroglycan in prostate cancer in human tissue samples and in LNCaP cells in vitro. There is progressive loss of beta-dystroglycan immunoreactivity from basal and lateral surfaces of prostate epithelia which correlates significantly with increasing Gleason grade. In about half of matched bone metastases there is significant dystroglycan re-expression. In tumour tissue and in LNCaP cells there is also a tyrosine phosphorylation-dependent translocation of beta-dystroglycan to the nucleus. Analysis of gene expression data by microarray, reveals that nuclear targeting of beta-dystroglycan in LNCaP cells alters the transcription of relatively few genes, the most unregulated being the transcription factor ETV1. These data suggest that proteolysis, tyrosine phosphorylation and translocation of dystroglycan to the nucleus resulting in altered gene transcription could be important mechanisms in the progression of prostate cancer.
dc.relation.isreferencedbyhttp://dx.doi.org/10.1038/srep02792
dc.subjectAndrogens
dc.subject; Cell Line
dc.subject; Cell nucleus
dc.subject; Dystroglycans
dc.subject; Gene expression regulation
dc.subject; Humans
dc.subject; Immunohistochemistry
dc.subject; Male
dc.subject; Myristic acid
dc.subject; Oligonucleotide array sequence analysis
dc.subject; Phosphorylation
dc.subject; Phosphotyrosine
dc.subject; Prostate
dc.subject; Prostatic neoplasms
dc.subject; Protein transport
dc.subject; Transcription factors
dc.subject; Transcription
dc.titleNuclear targeting of dystroglycan promotes the expression of androgen regulated transcription factors in prostate cancer
dc.typeArticle


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