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dc.contributor.authorDjidja, M-C.
dc.contributor.authorFrancese, S.
dc.contributor.authorClaude, E.
dc.contributor.authorLoadman, Paul M.
dc.contributor.authorSutton, Chris W.
dc.contributor.authorShnyder, Steven D.
dc.contributor.authorCooper, Patricia A.
dc.contributor.authorPatterson, Laurence H.
dc.contributor.authorCarolan, V.A.
dc.contributor.authorClench, M.R.
dc.date.accessioned2016-10-06T15:21:45Z
dc.date.available2016-10-06T15:21:45Z
dc.date.issued2013-04-01
dc.identifier.citationDjidja M, Francese S, Claude E et al (2013) Targeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDIIon Mobility Separation-Mass Spectrometry Imaging. Current Analytical Chemistry. 9(2): 212-225.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9533
dc.descriptionNoen_US
dc.description.abstractHypoxia is a common feature observed in solid tumours. It is a target of interest in oncology as it has been found to be closely associated with tumour progression, metastasis and aggressiveness and confers resistance to a variety of chemotherapeutic agents as well as radiotherapy. AQ4N, also known as banoxatrone or 1,4-bis-[2-(dimethylamino-Noxide) ethyl]amino-5,8-dihydroxyanthracene-9,10-dione is a very promising bioreductive prodrug. This paper, describes an application of MALDI-MSI combined with ion mobility separation and an "on-tissue" bottom up proteomic strategy to obtain proteomic data from AQ4N dosed tumour xenograft tissue sections. These data are then correlated with the drug distribution determined also using MALDI-ion mobility separation-mass spectrometry imaging (MALDI-IMS-MSI). PCA-DA and OPLS-DA have been used to compare treated and untreated xenografts and of note is the marked increase in expression of Histone H3.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttps://doi.org/10.2174/1573411011309020007en_US
dc.subjectAQ4N; Hypoxia; MALDI; ion mobility; mass spectrometry imagingen_US
dc.titleTargeting of Hypoxia in AQ4N-treated Tumour Xenografts by MALDI-Ion Mobility Separation-Mass Spectrometry Imagingen_US
dc.status.refereedyesen_US
dc.typeArticleen_US
dc.type.versionNo full-text in the repositoryen_US


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