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dc.contributor.authorRodríguez-Bárzano, A.*
dc.contributor.authorLord, Rianne M.*
dc.contributor.authorBasri, A.M.*
dc.contributor.authorPhillips, Roger M.*
dc.contributor.authorBlacker, A.J.*
dc.contributor.authorMcGowan, P.C.*
dc.date.accessioned2016-09-29T14:48:46Z
dc.date.available2016-09-29T14:48:46Z
dc.date.issued2015-02
dc.identifier.citationRodríguez-Bárzano A, Lord RM, Basri AM, Phillips RM, Blacker AJ and McGowan PC (2015) Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands. Dalton Transactions. 44: 3265-3270.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9498
dc.descriptionyesen_US
dc.description.abstractThe complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1039/c4dt02748een_US
dc.rights© 2015 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy.
dc.subject(η6-arene)-ruthenium; Anticancer agents; η5-C5(CH3)4R ruthenium complexesen_US
dc.titleSynthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligandsen_US
dc.status.refereedyesen_US
dc.date.Accepted2014-12-14
dc.date.application2015-01-05
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
refterms.dateFOA2018-07-25T14:34:23Z


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