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    Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

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    Rodriguez-Barzano_Dalton Trans_2015.pdf (868.4Kb)
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    Publication date
    2015-02
    Author
    Rodríguez-Bárzano, A.
    Lord, Rianne M.
    Basri, A.M.
    Phillips, Roger M.
    Blacker, A.J.
    McGowan, P.C.
    Keyword
    (η6-arene)-ruthenium; Anticancer agents; η5-C5(CH3)4R ruthenium complexes
    Rights
    © 2015 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy.
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.
    URI
    http://hdl.handle.net/10454/9498
    Version
    Accepted manuscript
    Citation
    Rodríguez-Bárzano A, Lord RM, Basri AM, Phillips RM, Blacker AJ and McGowan PC (2015) Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands. Dalton Transactions. 44: 3265-3270.
    Link to publisher’s version
    http://dx.doi.org/10.1039/c4dt02748e
    Type
    Article
    Collections
    Life Sciences Publications

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