Show simple item record

dc.contributor.authorLord, Rianne M.*
dc.contributor.authorMannion, J.J.*
dc.contributor.authorHebden, A.J.*
dc.contributor.authorNako, A.E.*
dc.contributor.authorCrossley, B.D.*
dc.contributor.authorMcMullon, M.W.*
dc.contributor.authorJaneway, F.D.*
dc.contributor.authorPhillips, Roger M.*
dc.contributor.authorMcGowan, P.C.*
dc.date.accessioned2016-09-29T14:13:10Z
dc.date.available2016-09-29T14:13:10Z
dc.date.issued2014-06
dc.identifier.citationLord RM, Mannion JJ, Hebden AJ, Nako AE, Crossley BD, McMullon MW, Janeway FD, Phillips RM and McGowan PC (2014) Mechanistic and Cytotoxicity Studies of Group IV b-Diketonate Complexes. ChemMedChem. 9(6): 1136–1139.
dc.identifier.urihttp://hdl.handle.net/10454/9495
dc.descriptionNo
dc.description.abstractGroup IV metal complexes have previously shown promise as novel anticancer agents. Here, we discuss the mechanistic and cytotoxic nature of a series of group IV b-diketonate coordination complexes. Clear evidence that the ligands are exchangeable on the metal centre and that the b-diketonate ligands can act as potential drug delivery vehicles of the group IV metal ions was obtained. When evaluated for the cytotoxicity against human colon adenocarcinoma (HT-29) and human breast adenocarcinoma (MCF-7) cell lines, a general trend of decreasing potency down the group IV metals was observed. The most promising results obtained were for the hafnium complexes, with the tris diphenyl b-diketonate hafnium complex exhibiting IC50 values of 4.9 0.9 mm and 3.2 0.3 mm against HT-29 and MCF-7, respectively, which are comparable with the activity of cisplatin against the same cell lines. This tri b-diketonate hafnium complex is the first to show potent in vitro cytotoxic activity. The results reported show that ligand design has a significant effect on the cytotoxic potential of the complexes, and that these group IV complexes warrant further evaluation as novel metal-containing anticancer agents.
dc.language.isoen
dc.subjectCytotoxicity
dc.subjectGroup IV b-Diketonate Complexes
dc.subjectAnticancer agents
dc.titleMechanistic and Cytotoxicity Studies of Group IV b-Diketonate Complexes
dc.status.refereedYes
dc.typeArticle
dc.type.versionNo full-text in the repository
dc.identifier.doihttps://doi.org/10.1002/cmdc.201402019
dc.openaccess.statusclosedAccess


Item file(s)

Thumbnail
Name:
Accepted ChemMedChem_Group IV ...
Size:
1.070Mb
Format:
PDF
Description:
keep suppressed - published version

This item appears in the following Collection(s)

Show simple item record