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    Mechanistic and Cytotoxicity Studies of Group IV b-Diketonate Complexes

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    Publication date
    2014-06
    Author
    Lord, Rianne M.
    Mannion, J.J.
    Hebden, A.J.
    Nako, A.E.
    Crossley, B.D.
    McMullon, M.W.
    Janeway, F.D.
    Phillips, Roger M.
    McGowan, P.C.
    Keyword
    Cytotoxicity; Group IV b-Diketonate Complexes; Anticancer agents
    Peer-Reviewed
    yes
    
    Metadata
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    Abstract
    Group IV metal complexes have previously shown promise as novel anticancer agents. Here, we discuss the mechanistic and cytotoxic nature of a series of group IV b-diketonate coordination complexes. Clear evidence that the ligands are exchangeable on the metal centre and that the b-diketonate ligands can act as potential drug delivery vehicles of the group IV metal ions was obtained. When evaluated for the cytotoxicity against human colon adenocarcinoma (HT-29) and human breast adenocarcinoma (MCF-7) cell lines, a general trend of decreasing potency down the group IV metals was observed. The most promising results obtained were for the hafnium complexes, with the tris diphenyl b-diketonate hafnium complex exhibiting IC50 values of 4.9 0.9 mm and 3.2 0.3 mm against HT-29 and MCF-7, respectively, which are comparable with the activity of cisplatin against the same cell lines. This tri b-diketonate hafnium complex is the first to show potent in vitro cytotoxic activity. The results reported show that ligand design has a significant effect on the cytotoxic potential of the complexes, and that these group IV complexes warrant further evaluation as novel metal-containing anticancer agents.
    URI
    http://hdl.handle.net/10454/9495
    Version
    No full-text in the repository
    Citation
    Lord RM, Mannion JJ, Hebden AJ, Nako AE, Crossley BD, McMullon MW, Janeway FD, Phillips RM and McGowan PC (2014) Mechanistic and Cytotoxicity Studies of Group IV b-Diketonate Complexes. ChemMedChem. 9(6): 1136–1139.
    Link to publisher’s version
    http://dx.doi.org/10.1002/cmdc.201402019
    Type
    Article
    Collections
    Life Sciences Publications

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