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dc.contributor.authorLucas, S.J.*
dc.contributor.authorLord, Rianne M.*
dc.contributor.authorBasri, A.M.*
dc.contributor.authorAllison, Simon J.*
dc.contributor.authorPhillips, Roger M.*
dc.contributor.authorBlacker, A.J.*
dc.contributor.authorMcGowan, P.C.*
dc.date.accessioned2016-09-28T11:51:44Z
dc.date.available2016-09-28T11:51:44Z
dc.date.issued2016-04
dc.identifier.citationLucas SJ, Lord RM, Basri AM, Allison SJ, Phillips RM, Blacker AJ and McGowan PC (2016) Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes [Communication]. Dalton Transactions. 45(16): 6812.en_US
dc.identifier.urihttp://hdl.handle.net/10454/9489
dc.descriptionyesen_US
dc.description.abstractHere in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2]2 dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2]2 dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action.en_US
dc.language.isoenen_US
dc.relation.isreferencedbyhttp://dx.doi.org/10.1039/C6DT00186Fen_US
dc.rights© 2016 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy.
dc.subjectAnti-cancer activity; Cytotoxicity; Cp* complexesen_US
dc.titleIncreasing anti-cancer activity with longer tether lengths of group 9 Cp* complexesen_US
dc.status.refereedyesen_US
dc.date.application2016-02-17
dc.typeArticleen_US
dc.type.versionAccepted manuscripten_US
refterms.dateFOA2018-07-25T15:01:00Z


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