Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes
dc.contributor.author | Lucas, S.J. | * |
dc.contributor.author | Lord, Rianne M. | * |
dc.contributor.author | Basri, A.M. | * |
dc.contributor.author | Allison, Simon J. | * |
dc.contributor.author | Phillips, Roger M. | * |
dc.contributor.author | Blacker, A.J. | * |
dc.contributor.author | McGowan, P.C. | * |
dc.date.accessioned | 2016-09-28T11:51:44Z | |
dc.date.available | 2016-09-28T11:51:44Z | |
dc.date.issued | 2016-04 | |
dc.identifier.citation | Lucas SJ, Lord RM, Basri AM, Allison SJ, Phillips RM, Blacker AJ and McGowan PC (2016) Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes [Communication]. Dalton Transactions. 45(16): 6812. | en_US |
dc.identifier.uri | http://hdl.handle.net/10454/9489 | |
dc.description | yes | en_US |
dc.description.abstract | Here in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2]2 dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2]2 dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action. | en_US |
dc.language.iso | en | en_US |
dc.rights | © 2016 RSC. Reproduced with permission from the publisher in accordance with the publisher's self-archiving policy. | |
dc.subject | Anti-cancer activity; Cytotoxicity; Cp* complexes | en_US |
dc.title | Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes | en_US |
dc.status.refereed | yes | en_US |
dc.date.application | 2016-02-17 | |
dc.type | Article | en_US |
dc.type.version | Accepted manuscript | en_US |
dc.identifier.doi | https://doi.org/10.1039/C6DT00186F | |
refterms.dateFOA | 2018-07-25T15:01:00Z |